Risk factors for rate of decline in FEV1 in adults with cystic fibrosis

Michael W. Konstan, Jeffrey S. Wagener, Donald R. VanDevanter, David J. Pasta, Ashley Yegin, Lawrence Rasouliyan, Wayne J. Morgan

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Background: Previously we assessed risk factors for FEV1 decline in children and adolescents using the Epidemiologic Study of Cystic Fibrosis (J Pediatr 2007;151:134-139); the current study assessed risk factors in adults. Methods: Risk factors for FEV1 decline over 3-5.5years for ages 18-24 and ≥25years were assessed using mixed-model regression. Results: Mean rates of FEV1 decline (% predicted/year) were -1.92 for ages 18-24y (n=2793) and -1.45 for ages ≥25y (n=1368). For the 18-24y group, B. cepacia, pancreatic enzyme use, multidrug-resistant P. aeruginosa, cough, mucoid P. aeruginosa, and female sex predicted greater decline; low baseline FEV1 and sinusitis predicted less decline. For the ≥25y group, only pancreatic enzyme use predicted greater decline; low baseline FEV1 and sinusitis predicted less decline. Conclusions: Risk factors for FEV1 decline in adults <25years are similar to those previously identified in children and adolescents; older adults had few statistically significant risk factors.

Original languageEnglish (US)
Pages (from-to)405-411
Number of pages7
JournalJournal of Cystic Fibrosis
Volume11
Issue number5
DOIs
StatePublished - Sep 1 2012

Keywords

  • Cystic fibrosis
  • Epidemiology
  • FEV
  • Rate of decline
  • Risk factors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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    Konstan, M. W., Wagener, J. S., VanDevanter, D. R., Pasta, D. J., Yegin, A., Rasouliyan, L., & Morgan, W. J. (2012). Risk factors for rate of decline in FEV1 in adults with cystic fibrosis. Journal of Cystic Fibrosis, 11(5), 405-411. https://doi.org/10.1016/j.jcf.2012.03.009