Risk factors for rate of decline in FEV1 in adults with cystic fibrosis

Michael W. Konstan; Jeffrey S. Wagener; Donald R. VanDevanter; David J. Pasta; Ashley Yegin; Lawrence Rasouliyan; Wayne J. Morgan

doi:10.1016/j.jcf.2012.03.009

Risk factors for rate of decline in FEV₁ in adults with cystic fibrosis

Michael W. Konstan, Jeffrey S. Wagener, Donald R. VanDevanter, David J. Pasta, Ashley Yegin, Lawrence Rasouliyan, Wayne J. Morgan

Pediatrics

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Background: Previously we assessed risk factors for FEV₁ decline in children and adolescents using the Epidemiologic Study of Cystic Fibrosis (J Pediatr 2007;151:134-139); the current study assessed risk factors in adults. Methods: Risk factors for FEV₁ decline over 3-5.5years for ages 18-24 and ≥25years were assessed using mixed-model regression. Results: Mean rates of FEV₁ decline (% predicted/year) were -1.92 for ages 18-24y (n=2793) and -1.45 for ages ≥25y (n=1368). For the 18-24y group, B. cepacia, pancreatic enzyme use, multidrug-resistant P. aeruginosa, cough, mucoid P. aeruginosa, and female sex predicted greater decline; low baseline FEV₁ and sinusitis predicted less decline. For the ≥25y group, only pancreatic enzyme use predicted greater decline; low baseline FEV₁ and sinusitis predicted less decline. Conclusions: Risk factors for FEV₁ decline in adults <25years are similar to those previously identified in children and adolescents; older adults had few statistically significant risk factors.

Original language	English (US)
Pages (from-to)	405-411
Number of pages	7
Journal	Journal of Cystic Fibrosis
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/j.jcf.2012.03.009
State	Published - Sep 2012

Keywords

Cystic fibrosis
Epidemiology
FEV
Rate of decline
Risk factors

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

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10.1016/j.jcf.2012.03.009

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@article{06a63c4ea7284d6aad9aed1f74f78528,

title = "Risk factors for rate of decline in FEV1 in adults with cystic fibrosis",

abstract = "Background: Previously we assessed risk factors for FEV1 decline in children and adolescents using the Epidemiologic Study of Cystic Fibrosis (J Pediatr 2007;151:134-139); the current study assessed risk factors in adults. Methods: Risk factors for FEV1 decline over 3-5.5years for ages 18-24 and ≥25years were assessed using mixed-model regression. Results: Mean rates of FEV1 decline (% predicted/year) were -1.92 for ages 18-24y (n=2793) and -1.45 for ages ≥25y (n=1368). For the 18-24y group, B. cepacia, pancreatic enzyme use, multidrug-resistant P. aeruginosa, cough, mucoid P. aeruginosa, and female sex predicted greater decline; low baseline FEV1 and sinusitis predicted less decline. For the ≥25y group, only pancreatic enzyme use predicted greater decline; low baseline FEV1 and sinusitis predicted less decline. Conclusions: Risk factors for FEV1 decline in adults <25years are similar to those previously identified in children and adolescents; older adults had few statistically significant risk factors.",

keywords = "Cystic fibrosis, Epidemiology, FEV, Rate of decline, Risk factors",

author = "Konstan, {Michael W.} and Wagener, {Jeffrey S.} and VanDevanter, {Donald R.} and Pasta, {David J.} and Ashley Yegin and Lawrence Rasouliyan and Morgan, {Wayne J.}",

note = "Funding Information: The authors gratefully acknowledge the more than 400 site investigators and coordinators in ESCF. This study is sponsored by Genentech, Inc.",

year = "2012",

month = sep,

doi = "10.1016/j.jcf.2012.03.009",

language = "English (US)",

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pages = "405--411",

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TY - JOUR

T1 - Risk factors for rate of decline in FEV1 in adults with cystic fibrosis

AU - Konstan, Michael W.

AU - Wagener, Jeffrey S.

AU - VanDevanter, Donald R.

AU - Pasta, David J.

AU - Yegin, Ashley

AU - Rasouliyan, Lawrence

AU - Morgan, Wayne J.

N1 - Funding Information: The authors gratefully acknowledge the more than 400 site investigators and coordinators in ESCF. This study is sponsored by Genentech, Inc.

PY - 2012/9

Y1 - 2012/9

N2 - Background: Previously we assessed risk factors for FEV1 decline in children and adolescents using the Epidemiologic Study of Cystic Fibrosis (J Pediatr 2007;151:134-139); the current study assessed risk factors in adults. Methods: Risk factors for FEV1 decline over 3-5.5years for ages 18-24 and ≥25years were assessed using mixed-model regression. Results: Mean rates of FEV1 decline (% predicted/year) were -1.92 for ages 18-24y (n=2793) and -1.45 for ages ≥25y (n=1368). For the 18-24y group, B. cepacia, pancreatic enzyme use, multidrug-resistant P. aeruginosa, cough, mucoid P. aeruginosa, and female sex predicted greater decline; low baseline FEV1 and sinusitis predicted less decline. For the ≥25y group, only pancreatic enzyme use predicted greater decline; low baseline FEV1 and sinusitis predicted less decline. Conclusions: Risk factors for FEV1 decline in adults <25years are similar to those previously identified in children and adolescents; older adults had few statistically significant risk factors.

AB - Background: Previously we assessed risk factors for FEV1 decline in children and adolescents using the Epidemiologic Study of Cystic Fibrosis (J Pediatr 2007;151:134-139); the current study assessed risk factors in adults. Methods: Risk factors for FEV1 decline over 3-5.5years for ages 18-24 and ≥25years were assessed using mixed-model regression. Results: Mean rates of FEV1 decline (% predicted/year) were -1.92 for ages 18-24y (n=2793) and -1.45 for ages ≥25y (n=1368). For the 18-24y group, B. cepacia, pancreatic enzyme use, multidrug-resistant P. aeruginosa, cough, mucoid P. aeruginosa, and female sex predicted greater decline; low baseline FEV1 and sinusitis predicted less decline. For the ≥25y group, only pancreatic enzyme use predicted greater decline; low baseline FEV1 and sinusitis predicted less decline. Conclusions: Risk factors for FEV1 decline in adults <25years are similar to those previously identified in children and adolescents; older adults had few statistically significant risk factors.

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KW - Rate of decline

KW - Risk factors

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