Risk factors for squamous intraepithelial lesions (SIL) of the cervix among women residing at the US-Mexico border

Anna R. Giuliano, Mary Papenfuss, Elena Mendez Brown De Galaz, Janine Feng, Martha Abrahamsen, Catalina Denman, Jill G De Zapien, Jose Luis Navarro Henze, Francisco A Garcia, Kenneth D Hatch

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

It is now well established that cervical cancer is caused by oncogenic human papillomavirus (HPV) infections that commonly infect women worldwide. What remains to be understood are the factors that contribute to cervical cancer in the presence of HPV infection. We conducted a case-control analysis of women recruited at the US-Mexico border to simultaneously evaluate factors associated with 3 cytologic outcomes: atypical squamous cells of undetermined significance or atypical glandular cells of undetermined significance (ASCUS/AGUS), low grade squamous intraepithelial lesions (LSIL) and high grade squamous intraepithelial lesions (HSIL). A cross-sectional binational study of 2,059 women ages 15-79 years was conducted between 1997 and 1998. A significant difference in the distribution of cytologic categories by country was observed (3.0% vs. 0.7% HSIL among Mexican vs. US women, respectively). The only factors independently associated with all 3 cytologic outcomes were HPV infection and viral load. A linear increase in risk with increasing viral load was observed for each of the 3 outcome variables, with the strength of this association increasing with cytology abnormality. In addition to HPV infection, parity and Mexico as a country of residence appear to be associated with LSIL and HSIL, respectively. Factors associated with cytologic outcomes in analyses limited to women with HPV infection were similar to results obtained in models where HPV infection was included as a covariate. Future work is needed to evaluate the predictive value of HPV viral load utilizing more specific and quantitative measures.

Original languageEnglish (US)
Pages (from-to)112-118
Number of pages7
JournalInternational Journal of Cancer
Volume109
Issue number1
DOIs
StatePublished - Mar 10 2004

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Mexico
Papillomavirus Infections
Viral Load
Uterine Cervical Neoplasms
Parity
Squamous Intraepithelial Lesions of the Cervix
Cell Biology
Cross-Sectional Studies

Keywords

  • Cervical cancer
  • Cervical dysplasia
  • HPV
  • Squamous intraepithelial lesions
  • Viral load

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Risk factors for squamous intraepithelial lesions (SIL) of the cervix among women residing at the US-Mexico border. / Giuliano, Anna R.; Papenfuss, Mary; Mendez Brown De Galaz, Elena; Feng, Janine; Abrahamsen, Martha; Denman, Catalina; De Zapien, Jill G; Navarro Henze, Jose Luis; Garcia, Francisco A; Hatch, Kenneth D.

In: International Journal of Cancer, Vol. 109, No. 1, 10.03.2004, p. 112-118.

Research output: Contribution to journalArticle

Giuliano, AR, Papenfuss, M, Mendez Brown De Galaz, E, Feng, J, Abrahamsen, M, Denman, C, De Zapien, JG, Navarro Henze, JL, Garcia, FA & Hatch, KD 2004, 'Risk factors for squamous intraepithelial lesions (SIL) of the cervix among women residing at the US-Mexico border', International Journal of Cancer, vol. 109, no. 1, pp. 112-118. https://doi.org/10.1002/ijc.11656
Giuliano AR, Papenfuss M, Mendez Brown De Galaz E, Feng J, Abrahamsen M, Denman C et al. Risk factors for squamous intraepithelial lesions (SIL) of the cervix among women residing at the US-Mexico border. International Journal of Cancer. 2004 Mar 10;109(1):112-118. https://doi.org/10.1002/ijc.11656
Giuliano, Anna R. ; Papenfuss, Mary ; Mendez Brown De Galaz, Elena ; Feng, Janine ; Abrahamsen, Martha ; Denman, Catalina ; De Zapien, Jill G ; Navarro Henze, Jose Luis ; Garcia, Francisco A ; Hatch, Kenneth D. / Risk factors for squamous intraepithelial lesions (SIL) of the cervix among women residing at the US-Mexico border. In: International Journal of Cancer. 2004 ; Vol. 109, No. 1. pp. 112-118.
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