Risk factors for subclinical atherosclerosis in firefighters

Jefferey L Burgess, Margaret Kurzius-Spencer, Richard D. Gerkin, James L. Fleming, Wayne F. Peate, Matthew Allison

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: Heart disease is the leading cause of firefighter line-of-duty deaths. The study objectives were to identify early atherosclerotic disease through ultrasound measurement of carotid intima-media thickness (CIMT) and risk factors predicting increased CIMT and carotid plaque. Methods: Following ultrasound evaluation of 597 Phoenix and Tucson firefighters, logistic regression was used to identify risk factors formean CIMT greater than 75th percentile and for carotid plaque. Results: Age, low-density lipoprotein cholesterol (LDL-C) of 100 mg/dL or more, and high-density lipoprotein cholesterol were significant independent predictors of increased CIMT. Age, hypertension, LDL-C, and plasma soluble P-selectin were significant predictors of carotid plaque. Conclusions: This study supports an emphasis on traditional risk factors for atherosclerotic disease in firefighters, in particular maintaining LDL-C less than 100 mg/dL. Plasma soluble P-selectin may help identify firefighters at increased risk for carotid plaque.

Original languageEnglish (US)
Pages (from-to)328-335
Number of pages8
JournalJournal of occupational and environmental medicine / American College of Occupational and Environmental Medicine
Volume54
Issue number3
DOIs
StatePublished - Mar 2012

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Firefighters
Carotid Intima-Media Thickness
Atherosclerosis
LDL Cholesterol
P-Selectin
HDL Cholesterol
Heart Diseases
Logistic Models
Hypertension

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Risk factors for subclinical atherosclerosis in firefighters. / Burgess, Jefferey L; Kurzius-Spencer, Margaret; Gerkin, Richard D.; Fleming, James L.; Peate, Wayne F.; Allison, Matthew.

In: Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine, Vol. 54, No. 3, 03.2012, p. 328-335.

Research output: Contribution to journalArticle

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