Risk factors for subclinical atherosclerosis in firefighters

Jefferey L. Burgess, Margaret Kurzius-Spencer, Richard D. Gerkin, James L. Fleming, Wayne F. Peate, Matthew Allison

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Objective: Heart disease is the leading cause of firefighter line-of-duty deaths. The study objectives were to identify early atherosclerotic disease through ultrasound measurement of carotid intima-media thickness (CIMT) and risk factors predicting increased CIMT and carotid plaque. Methods: Following ultrasound evaluation of 597 Phoenix and Tucson firefighters, logistic regression was used to identify risk factors formean CIMT greater than 75th percentile and for carotid plaque. Results: Age, low-density lipoprotein cholesterol (LDL-C) of 100 mg/dL or more, and high-density lipoprotein cholesterol were significant independent predictors of increased CIMT. Age, hypertension, LDL-C, and plasma soluble P-selectin were significant predictors of carotid plaque. Conclusions: This study supports an emphasis on traditional risk factors for atherosclerotic disease in firefighters, in particular maintaining LDL-C less than 100 mg/dL. Plasma soluble P-selectin may help identify firefighters at increased risk for carotid plaque.

Original languageEnglish (US)
Pages (from-to)328-335
Number of pages8
JournalJournal of occupational and environmental medicine
Volume54
Issue number3
DOIs
StatePublished - Mar 1 2012

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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