Role of 5HT1A receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness towards man

Ella M. Nikulina, Damira F. Avgustinovich, Nina K. Popova

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The 5HT1A receptor agonist ipsapirone (10 mg/kg) suppressed shock‐induced aggression in wild and domesticated rats but did not affect predatory aggression in either group of animals. Ipsapirone decreased neophobia and inhibited defensive reactions by wild rats towards man in the glove test. [3H]8‐OH‐DPAT binding, which labels 5HT1A receptors, was significantly increased in the hypothalamus of domesticated rats in comparison with wild counterparts, while 5HT1A density was unchanged in the frontal cortex in domesticated animals. In essence, the aggressive reactions contributing to the defensive behavior complex in wild rats appear to be regulated through 5HT1A receptors. © 1992 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)357-364
Number of pages8
JournalAggressive behavior
Volume18
Issue number5
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • domestication
  • ipsapirone
  • neophobia
  • serotonin

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Psychology(all)

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