Role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion

Christopher L. Mendias, Ryuichi Tatsumi, Ronald E Allen

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Skeletal muscle satellite cells play an important role in muscle regeneration. Previous work has suggested that nonsteroidal anti-inflammatory drugs may inhibit their activity. We cultured skeletal muscle satellite cells from 9-month-old Sprague-Dawley rats and exposed them to naproxen sodium (a nonselective cyclooxygenase inhibitor), NS-398 (a selective cyclooxygenase-2 inhibitor), and SC-560 (a selective cyclooxygenase-1 inhibitor) for 96 h. Cyclooxygenase-2 inhibition alone resulted in decreased satellite cell proliferation, and inhibition of both cyclooxygenase-1 and cyclooxygenase-2 resulted in decreased satellite cell differentiation and fusion. This study suggests that the cyclooxygenase enzymes appear to play an important part in satellite cell proliferation, differentiation, and fusion and that nonsteroidal anti-inflammatory medication may have an adverse effect on muscle regeneration following injury. The use of a selective cyclooxygenase-2 inhibitor over nonspecific cyclooxygenase inhibitors in the treatment of muscle injuries is not supported.

Original languageEnglish (US)
Pages (from-to)497-500
Number of pages4
JournalMuscle and Nerve
Volume30
Issue number4
DOIs
StatePublished - Oct 2004

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Cyclooxygenase 1
Cyclooxygenase Inhibitors
Cell Fusion
Cyclooxygenase 2
Skeletal Muscle Satellite Cells
Cell Differentiation
Cyclooxygenase 2 Inhibitors
Cell Proliferation
Muscles
Regeneration
Anti-Inflammatory Agents
Naproxen
Wounds and Injuries
Prostaglandin-Endoperoxide Synthases
Sprague Dawley Rats
Enzymes
Pharmaceutical Preparations

Keywords

  • Cyclooxygenase
  • Muscle regeneration
  • NSAID
  • Prostaglandin
  • Satellite cell

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion. / Mendias, Christopher L.; Tatsumi, Ryuichi; Allen, Ronald E.

In: Muscle and Nerve, Vol. 30, No. 4, 10.2004, p. 497-500.

Research output: Contribution to journalArticle

Mendias, Christopher L. ; Tatsumi, Ryuichi ; Allen, Ronald E. / Role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion. In: Muscle and Nerve. 2004 ; Vol. 30, No. 4. pp. 497-500.
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