TY - JOUR
T1 - Role of dietary patterns and acculturation in cancer risk and mortality among postmenopausal Hispanic women
T2 - results from the Women’s Health Initiative (WHI)
AU - Lopez-Pentecost, Melissa
AU - Crane, Tracy E.
AU - Garcia, David O.
AU - Kohler, Lindsay N.
AU - Wertheim, Betsy C.
AU - Hebert, James R.
AU - Steck, Susan E.
AU - Shivappa, Nitin
AU - Santiago-Torres, Margarita
AU - Neuhouser, Marian L.
AU - Hatsu, Irene E.
AU - Snetselaar, Linda
AU - Datta, Mridul
AU - Kroenke, Candyce H.
AU - Sarto, Gloria E.
AU - Thomson, Cynthia A.
N1 - Funding Information:
The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, and US Department of Health and Human Services through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C.
PY - 2020
Y1 - 2020
N2 - Aim: To investigate the association between dietary patterns and total and obesity-related cancer risk as well as to examine if acculturation modifies this relationship. Subjects and methods: Dietary intake of postmenopausal Hispanic women (N = 5,482) enrolled in the Women’s Health Initiative was estimated from a Food Frequency Questionnaire and used to calculate dietary pattern scores: Healthy Eating Index-2015 (HEI-2015), Mexican Diet (MexD) score, alternate Mediterranean Diet Score (aMED), and the energy adjusted Dietary Inflammatory Index (E-DII™). Associations were evaluated using Cox proportional hazard regression models. Results: Six hundred thirty-one cancers and 396 obesity-related cancers were diagnosed over a mean follow-up of 12 years. Across dietary scores, there were no significant associations with cancer risk or mortality. Trend analysis suggested a potentially lower risk for total cancer mortality related to the highest MexD score (HR 0.68, 95% CI 0.45–1.04, P-trend = 0.03) and lower risk for obesity-related cancer mortality related to the highest score category for MexD (HR 0.65, 95% CI 0.37–1.16, P-trend = 0.02) and aMED (HR 0.87, 95% CI 0.45–1.67, P-trend = 0.04). Further analysis suggested less acculturated women with higher MexD scores had a 56% lower risk for any cancer (HR 0.44, 95% CI 0.22–0.88, P-trend = 0.03) and 83% lower risk for cancer mortality (HR 0.17, 95% CI 0.04–0.76, P-trend = 0.01) compared to more acculturated Hispanic women. Conclusions: Dietary patterns were not associated with cancer risk and mortality in postmenopausal Hispanic women. Less acculturated, Spanish-preferred speakers who report consuming a more traditional Mexican diet may experience a lower risk of cancer and cancer mortality.
AB - Aim: To investigate the association between dietary patterns and total and obesity-related cancer risk as well as to examine if acculturation modifies this relationship. Subjects and methods: Dietary intake of postmenopausal Hispanic women (N = 5,482) enrolled in the Women’s Health Initiative was estimated from a Food Frequency Questionnaire and used to calculate dietary pattern scores: Healthy Eating Index-2015 (HEI-2015), Mexican Diet (MexD) score, alternate Mediterranean Diet Score (aMED), and the energy adjusted Dietary Inflammatory Index (E-DII™). Associations were evaluated using Cox proportional hazard regression models. Results: Six hundred thirty-one cancers and 396 obesity-related cancers were diagnosed over a mean follow-up of 12 years. Across dietary scores, there were no significant associations with cancer risk or mortality. Trend analysis suggested a potentially lower risk for total cancer mortality related to the highest MexD score (HR 0.68, 95% CI 0.45–1.04, P-trend = 0.03) and lower risk for obesity-related cancer mortality related to the highest score category for MexD (HR 0.65, 95% CI 0.37–1.16, P-trend = 0.02) and aMED (HR 0.87, 95% CI 0.45–1.67, P-trend = 0.04). Further analysis suggested less acculturated women with higher MexD scores had a 56% lower risk for any cancer (HR 0.44, 95% CI 0.22–0.88, P-trend = 0.03) and 83% lower risk for cancer mortality (HR 0.17, 95% CI 0.04–0.76, P-trend = 0.01) compared to more acculturated Hispanic women. Conclusions: Dietary patterns were not associated with cancer risk and mortality in postmenopausal Hispanic women. Less acculturated, Spanish-preferred speakers who report consuming a more traditional Mexican diet may experience a lower risk of cancer and cancer mortality.
KW - Acculturation
KW - Cancer
KW - Dietary pattern
KW - Hispanic women
KW - Mexican diet
UR - http://www.scopus.com/inward/record.url?scp=85087916667&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85087916667&partnerID=8YFLogxK
U2 - 10.1007/s10389-020-01342-8
DO - 10.1007/s10389-020-01342-8
M3 - Article
AN - SCOPUS:85087916667
JO - Zeitschrift fur Gesundheitswissenschaften
JF - Zeitschrift fur Gesundheitswissenschaften
SN - 0943-1853
ER -