Role of genotype and dopamine receptors in behaviour of inbred mice in a forced swimming test

Ella M Nikulina, Julia A. Skrinskaya, Nina K. Popova

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The role of genotype in the effects of selective D1 and D2 dopamine agonists and antagonists on behavioural despair (Porsolt's test) was studied. Mice of nine inbred strains showed significant interstrain differences in duration of immobility. The influence of dopaminergic drugs was assessed in six strains characterized by different levels of swimming activity. SKF 38393 (10 mg/kg), an agonist at D1 dopamine receptors, increased swimming activity, while the D1 antagonist SCH 23390 (0.2 and 0.5 mg/kg) reduced it, the effects being genotype dependent. The involvement of D2 dopamine receptors in the regulation of mouse behaviour in the forced swimming test was not so evident; the D2 agonist bromocriptine (10 mg/kg) produced no significant effect. The D2 agonist quinpirole (2.5 mg/kg) increased immobility in the majority of the mouse strains studied, while in CBA mice it resulted in a marked reduction of immobility. The D2 antagonist sulpiride (20 mg/kg) decreased immobility and increased active swimming only in two strains. The present results suggest a different role for D1 and D2 dopamine receptors in the regulation of swimming in the mouse.

Original languageEnglish (US)
Pages (from-to)525-529
Number of pages5
JournalPsychopharmacology
Volume105
Issue number4
DOIs
StatePublished - Dec 1991
Externally publishedYes

Fingerprint

Dopamine Receptors
Genotype
Dopamine D1 Receptors
Dopamine D2 Receptors
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Quinpirole
Sulpiride
Inbred CBA Mouse
Dopamine Agents
Inbred Strains Mice
Bromocriptine
Dopamine Antagonists
Dopamine Agonists

Keywords

  • Behavioral despair test
  • D1 and D2 dopamine receptors
  • Genotype
  • Mouse

ASJC Scopus subject areas

  • Pharmacology

Cite this

Role of genotype and dopamine receptors in behaviour of inbred mice in a forced swimming test. / Nikulina, Ella M; Skrinskaya, Julia A.; Popova, Nina K.

In: Psychopharmacology, Vol. 105, No. 4, 12.1991, p. 525-529.

Research output: Contribution to journalArticle

Nikulina, Ella M ; Skrinskaya, Julia A. ; Popova, Nina K. / Role of genotype and dopamine receptors in behaviour of inbred mice in a forced swimming test. In: Psychopharmacology. 1991 ; Vol. 105, No. 4. pp. 525-529.
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