Abstract
Motoneurons in most organisms conserve a division into low-threshold and high-threshold types that are responsible for generating powerful and precise movements. Drosophila 1b and 1s motoneurons may be analogous to low-threshold and high-threshold neurons, respectively, based on data obtained at the neuromuscular junction, although there is little information available on intrinsic properties or recruitment during behavior. Therefore in situ whole cell patch-clamp recordings were used to compare parameters of 1b and 1s motoneurons in Drosophila larvae. We find that resting membrane potential, voltage threshold, and delay-to-spike distinguish 1b from 1s motoneurons. The longer delay-to-spike in 1s motoneurons is a result of the shal-encoded A-type K+ current. Functional differences between 1b and 1s motoneurons are behaviorally relevant because a higher threshold and longer delay-to-spike are observed in MNISN-1s in pairwise whole cell recordings of synaptically evoked activity during bouts of fictive locomotion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1257-1266 |
| Number of pages | 10 |
| Journal | Journal of Neurophysiology |
| Volume | 104 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2010 |
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ASJC Scopus subject areas
- Physiology
- Neuroscience(all)
Cite this
Role of intrinsic properties in Drosophila motoneuron recruitment during fictive crawling. / Schaefer, Jennifer E.; Worrell, Jason W.; Levine, Richard B.
In: Journal of Neurophysiology, Vol. 104, No. 3, 09.2010, p. 1257-1266.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of intrinsic properties in Drosophila motoneuron recruitment during fictive crawling
AU - Schaefer, Jennifer E.
AU - Worrell, Jason W.
AU - Levine, Richard B
PY - 2010/9
Y1 - 2010/9
N2 - Motoneurons in most organisms conserve a division into low-threshold and high-threshold types that are responsible for generating powerful and precise movements. Drosophila 1b and 1s motoneurons may be analogous to low-threshold and high-threshold neurons, respectively, based on data obtained at the neuromuscular junction, although there is little information available on intrinsic properties or recruitment during behavior. Therefore in situ whole cell patch-clamp recordings were used to compare parameters of 1b and 1s motoneurons in Drosophila larvae. We find that resting membrane potential, voltage threshold, and delay-to-spike distinguish 1b from 1s motoneurons. The longer delay-to-spike in 1s motoneurons is a result of the shal-encoded A-type K+ current. Functional differences between 1b and 1s motoneurons are behaviorally relevant because a higher threshold and longer delay-to-spike are observed in MNISN-1s in pairwise whole cell recordings of synaptically evoked activity during bouts of fictive locomotion.
AB - Motoneurons in most organisms conserve a division into low-threshold and high-threshold types that are responsible for generating powerful and precise movements. Drosophila 1b and 1s motoneurons may be analogous to low-threshold and high-threshold neurons, respectively, based on data obtained at the neuromuscular junction, although there is little information available on intrinsic properties or recruitment during behavior. Therefore in situ whole cell patch-clamp recordings were used to compare parameters of 1b and 1s motoneurons in Drosophila larvae. We find that resting membrane potential, voltage threshold, and delay-to-spike distinguish 1b from 1s motoneurons. The longer delay-to-spike in 1s motoneurons is a result of the shal-encoded A-type K+ current. Functional differences between 1b and 1s motoneurons are behaviorally relevant because a higher threshold and longer delay-to-spike are observed in MNISN-1s in pairwise whole cell recordings of synaptically evoked activity during bouts of fictive locomotion.
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UR - http://www.scopus.com/inward/citedby.url?scp=77957193850&partnerID=8YFLogxK
U2 - 10.1152/jn.00298.2010
DO - 10.1152/jn.00298.2010
M3 - Article
C2 - 20573969
AN - SCOPUS:77957193850
VL - 104
SP - 1257
EP - 1266
JO - Journal of Neurophysiology
JF - Journal of Neurophysiology
SN - 0022-3077
IS - 3
ER -