Role of intrinsic properties in Drosophila motoneuron recruitment during fictive crawling

Jennifer E. Schaefer, Jason W. Worrell, Richard B Levine

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Motoneurons in most organisms conserve a division into low-threshold and high-threshold types that are responsible for generating powerful and precise movements. Drosophila 1b and 1s motoneurons may be analogous to low-threshold and high-threshold neurons, respectively, based on data obtained at the neuromuscular junction, although there is little information available on intrinsic properties or recruitment during behavior. Therefore in situ whole cell patch-clamp recordings were used to compare parameters of 1b and 1s motoneurons in Drosophila larvae. We find that resting membrane potential, voltage threshold, and delay-to-spike distinguish 1b from 1s motoneurons. The longer delay-to-spike in 1s motoneurons is a result of the shal-encoded A-type K+ current. Functional differences between 1b and 1s motoneurons are behaviorally relevant because a higher threshold and longer delay-to-spike are observed in MNISN-1s in pairwise whole cell recordings of synaptically evoked activity during bouts of fictive locomotion.

Original languageEnglish (US)
Pages (from-to)1257-1266
Number of pages10
JournalJournal of Neurophysiology
Volume104
Issue number3
DOIs
StatePublished - Sep 2010

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Motor Neurons
Drosophila
Neuromuscular Junction
Patch-Clamp Techniques
Locomotion
Membrane Potentials
Larva
Neurons

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Role of intrinsic properties in Drosophila motoneuron recruitment during fictive crawling. / Schaefer, Jennifer E.; Worrell, Jason W.; Levine, Richard B.

In: Journal of Neurophysiology, Vol. 104, No. 3, 09.2010, p. 1257-1266.

Research output: Contribution to journalArticle

Schaefer, Jennifer E. ; Worrell, Jason W. ; Levine, Richard B. / Role of intrinsic properties in Drosophila motoneuron recruitment during fictive crawling. In: Journal of Neurophysiology. 2010 ; Vol. 104, No. 3. pp. 1257-1266.
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