Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations

Abstract

Organic cations (OCs) constitute a diverse array of compounds of physiological, pharmacological, and toxicological importance. Renal secretion of these compounds, which occurs principally along the proximal portion of the nephron, plays a critical role in regulating the concentration of OCs in the plasma and in clearing the body of potentially toxic xenobiotic OCs. Transepithelial OC transport in the kidney involves separate entry and exit steps at the basolateral and luminal aspects of renal tubular cells. It is increasingly apparent that basolateral and luminal OC transport reflects the concerted activity of a suite of separate transport processes arranged in parallel in each pole of proximal tubule cells. Most of the transporters that appear to dominate renal secretion of OCs belong to a single family of transport proteins: the OCT Family. The characterization of their activity, and their localization within distinct regions of the kidney, has permitted development of models describing the molecular and cellular basis of the renal secretion of OCs.

Original languageEnglish (US)
Pages (from-to)309-319
Number of pages11
JournalToxicology and Applied Pharmacology
Volume204
Issue number3
DOIs
StatePublished - Jan 1 2005

Keywords

  • Kidney
  • Organic cation
  • Renal secretion

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Fingerprint Dive into the research topics of 'Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics'. Together they form a unique fingerprint.

Cite this