Rol' fosforilirovania miozina na aktinsviazyvaiushchikh belkov v indutsirovannoi trombinom pronitsaemosti éndoteliia.

Translated title of the contribution: Role of phosphorylation of myosin and actin-binding proteins in endothelial permeability induced by thrombin

T. Borbiev, J. G. Garcia, A. D. Berin

Research output: Contribution to journalArticle

Abstract

The thrombin-induced dysfunction of the barrier function of the blood vessel endothelium, which manifests itself in increased permeability, is largely mediated via the initiation of specific receptors that trigger multiple signaling cascades, including the activation of some protein kinases and the phosphorylation of their cytoskeletal targets. The role of the phosphorylation of myosin and actin-binding proteins in the thrombin-induced permeability of the endothelium and possible mechanisms of the regulation of the endothelium barrier function are discussed.

Translated title of the contributionRole of phosphorylation of myosin and actin-binding proteins in endothelial permeability induced by thrombin
Original languageRussian
Pages (from-to)510-517
Number of pages8
JournalBioorganicheskaia khimiia
Volume29
Issue number5
StatePublished - 2003

ASJC Scopus subject areas

  • Medicine(all)

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