Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels

Michael Y. Song, Ayako Makino, Jason Yuan

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Cellular redox status, regulated by production of reactive oxygen species (ROS), greatly contributes to the regulation of vascular smooth muscle cell contraction, migration, proliferation, and apoptosis by modulating the function of transient receptor potential (TRP) channels in the plasma membrane. ROS functionally interact with the channel protein via oxidizing the redox-sensitive residues, whereas nitric oxide (NO) regulates TRP channel function by cyclic GMP/protein kinase G-dependent and-independent pathways. Based on the structural differences among different TRP isoforms, the effects of ROS and NO are also different. In addition to regulating TRP channels in the plasma membrane, ROS and NO also modulate Ca 2+ release channels (e.g., IP 3 and ryanodine receptors) on the sarcoplasmic/endoplasmic reticulum membrane. This review aims at briefly describing (a) the role of TRP channels in receptor-operated and store-operated Ca 2+ entry, and (b) the role of ROS and redox status in regulating the function and structure of TRP channels.

Original languageEnglish (US)
Pages (from-to)1549-1565
Number of pages17
JournalAntioxidants and Redox Signaling
Volume15
Issue number6
DOIs
StatePublished - Sep 15 2011
Externally publishedYes

Fingerprint

Transient Receptor Potential Channels
Oxidation-Reduction
Reactive Oxygen Species
Nitric Oxide
Cell membranes
Guanylate Kinases
Cell Membrane
Cyclic GMP-Dependent Protein Kinases
Ryanodine Receptor Calcium Release Channel
Cyclic GMP
Sarcoplasmic Reticulum
Muscle Contraction
Vascular Smooth Muscle
Endoplasmic Reticulum
Smooth Muscle Myocytes
Cell Movement
Muscle
Protein Isoforms
Cells
Apoptosis

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels. / Song, Michael Y.; Makino, Ayako; Yuan, Jason.

In: Antioxidants and Redox Signaling, Vol. 15, No. 6, 15.09.2011, p. 1549-1565.

Research output: Contribution to journalArticle

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