Role of reactive oxygen species (ROS) and JNKs in selenite-induced apoptosis in HepG2 cells

Durga P. Cherukuri, Mark A Nelson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Dietary selenium (Se) supplementation has been shown to be effective against reducing the risk of incidence of different human cancers.1 Selenium exists in both organic and inorganic forms. Different chemical forms of selenium metabolize differently in vivo, activate distinct molecular mechanisms and exhibit varying degree of anti-carcinogenicity in different cancer types.2-4 The effectiveness of a Se compound could also vary depending on the genetic background of the tumor cells.4 Therefore, understanding the molecular mechanism(s) by which different Se compounds exert their anti-tumorigenic effects is necessary for their use in cancer chemoprevention.

Original languageEnglish (US)
Pages (from-to)699-700
Number of pages2
JournalCancer Biology and Therapy
Volume7
Issue number5
StatePublished - May 2008

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Selenious Acid
Hep G2 Cells
Selenium
Selenium Compounds
Reactive Oxygen Species
Apoptosis
Neoplasms
Chemoprevention
Dietary Supplements
Incidence

Keywords

  • Apoptosis
  • HepG2
  • JNK
  • ROS
  • Selenite

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Role of reactive oxygen species (ROS) and JNKs in selenite-induced apoptosis in HepG2 cells. / Cherukuri, Durga P.; Nelson, Mark A.

In: Cancer Biology and Therapy, Vol. 7, No. 5, 05.2008, p. 699-700.

Research output: Contribution to journalArticle

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