Role of the area postrema in angiotensin II modulation of baroreflex control of heart rate in conscious mice

Baojian Xue, Hope Gole, Jaya Pamidimukkala, Meredith Hay

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

This study reports the effects of angiotensin II (ANG II), arginine vasopression (AVP), phenylephrine (PE), and sodium nitroprusside (SNP) on baroreflex control of heart rate in the presence and absence of the area postrema (AP) in conscious mice. In intact, shamlesioned mice, baroreflex-induced decreases in heart rate due to increases in arterial pressure with intravenous infusions of ANG II were significantly less than those observed with similar increases in arterial pressure with PE (slope: -3.0 ± 0.9 vs. -8.1 ± 1.5 beats·min-1·mmHg-1). Baroreflex-induced decreases in heart rate due to increases in arterial pressure with intravenous infusions of AVP were the same as those observed with PE in sham animals (slope: -5.8 ± 0.7 vs. -8.1 ± 1.5 beats·min-1·mmHg-1). After the AP was lesioned, the slope of baroreflex inhibition of heart rate was the same whether pressure was increased with ANG II, AVP, or PE. The slope of the baroreflex-induced increases in heart rate due to decreases in arterial blood pressure with SNP were the same in sham- and AP-lesioned animals. These results indicate that, similar to other species, in mice the ability of ANG II to acutely reset baroreflex control of heart rate is dependent on an intact AP.

Original languageEnglish (US)
Pages (from-to)H1003-H1007
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume284
Issue number3 53-3
DOIs
StatePublished - Mar 1 2003

Keywords

  • Autonomic nervous system
  • Circumventricular organs
  • Vasopressin

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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