Role of the medial septum and hippocampal theta rhythm in exploration-related synaptic efficacy changes in rat fascia dentata

E. J. Green, B. L. McNaughton, C. A. Barnes

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Animals transferred from their home cages to a different environment exhibited an increase in exploratory behavior which was accopanied by a substantial increase in perforant path-evoked population excitatory postsynaptic potentials and decreases in both the areas and the onset latencies of population spikes. As reported previously, these changes substantially outlasted the exploratory behaviors that induced them. Electrolytic lesions of the medial septum severely attenuated the theta rhythm of the hippocampal EEG, but had no significant effect on the exploration related changes in the synaptic and postsynaptic components of the evoked response. In urethane-anesthetized animals, long trains of hippocampal theta produced by sensory stimulation failed to affect the amplitude of evoked responses. These results show that the information critical for the exploration-related alterations in dentate evoked responses does not originate in or pass through the medial septum, and that the changes are not linked to hippocampal EEG states.

Original languageEnglish (US)
Pages (from-to)102-108
Number of pages7
JournalBrain Research
Volume529
Issue number1-2
DOIs
StatePublished - Oct 8 1990
Externally publishedYes

Keywords

  • Dentate gyrus
  • Exploration
  • Medial septum
  • Synaptic transmission
  • Theta

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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