RpoN and the Nps and Npa two-component regulatory system control pilE transcription in commensal Neisseria

María A. Rendón, Beatriz Lona, Mancheong Ma, Magdalene So

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Over 20 genes are involved in the biogenesis and function of the Neisseria Type IV pilus (Tfp). In the pathogenic species, RpoD and the integration host factor (IHF) protein regulate expression of pilE, encoding the Tfp structural subunit. We previously reported that in commensal species, pilE transcription is regulated by RpoN, IHF, and activator Npa. Npa has many hallmarks of response regulators in two-component regulatory systems, leading us to search for its response regulator partner. We report that Npa partners with sensor kinase Nps to control pilE transcription. Among the genes involved in Tfp biogenesis and function, only pilE is controlled by RpoN and Npa/Nps. We summarize our findings in a model, and discuss the implications of the differential regulation of pilE the context of Neisseria Tfp biogenesis.

Original languageEnglish (US)
Article numbere00713
JournalMicrobiologyOpen
Volume8
Issue number5
DOIs
StatePublished - May 2019

Keywords

  • Neisseria
  • Type IV fimbriae
  • transcription regulation
  • two-component sensors

ASJC Scopus subject areas

  • Microbiology

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