Abstract
Cis‐diamminedichloroplatinum (II) cis‐platinum, 25–75 mg/m2, with 40 gm mannitol and fluid were given over 1–2 hours to 40 patients with no evidence of elevated serum creatinine levels. Cis‐platinum was administered every 28 days at a dose of 50mg/m2 to 22 patients, and 75mg/m2 to 6 patients. Patients received from one to eight courses of therapy with no change in their serum creatinine level. A safe, simple method of cis‐platinum administration has been achieved.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 371-375 |
| Number of pages | 5 |
| Journal | Medical and Pediatric Oncology |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1978 |
Keywords
- cis‐platinum
- drug interaction
- mannitol
- renal toxicity
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Oncology
- Cancer Research
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Cite this
Rainey, J. M., & Alberts, D. S. (1978). Safe, rapid administration schedule for cis‐platinum—mannitol. Medical and Pediatric Oncology, 4(4), 371-375. https://doi.org/10.1002/mpo.2950040415