Safe, rapid administration schedule for cis‐platinum—mannitol

John M. Rainey, David S. Alberts

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Cis‐diamminedichloroplatinum (II) cis‐platinum, 25–75 mg/m2, with 40 gm mannitol and fluid were given over 1–2 hours to 40 patients with no evidence of elevated serum creatinine levels. Cis‐platinum was administered every 28 days at a dose of 50mg/m2 to 22 patients, and 75mg/m2 to 6 patients. Patients received from one to eight courses of therapy with no change in their serum creatinine level. A safe, simple method of cis‐platinum administration has been achieved.

Original languageEnglish (US)
Pages (from-to)371-375
Number of pages5
JournalMedical and Pediatric Oncology
Issue number4
StatePublished - 1978


  • cis‐platinum
  • drug interaction
  • mannitol
  • renal toxicity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research


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