Safe, rapid administration schedule for cis‐platinum—mannitol

John M. Rainey; David S. Alberts

doi:10.1002/mpo.2950040415

Safe, rapid administration schedule for cis‐platinum—mannitol

John M. Rainey, David S. Alberts

Cancer Center

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Cis‐diamminedichloroplatinum (II) cis‐platinum, 25–75 mg/m², with 40 gm mannitol and fluid were given over 1–2 hours to 40 patients with no evidence of elevated serum creatinine levels. Cis‐platinum was administered every 28 days at a dose of 50mg/m² to 22 patients, and 75mg/m² to 6 patients. Patients received from one to eight courses of therapy with no change in their serum creatinine level. A safe, simple method of cis‐platinum administration has been achieved.

Original language	English (US)
Pages (from-to)	371-375
Number of pages	5
Journal	Medical and Pediatric Oncology
Volume	4
Issue number	4
DOIs	https://doi.org/10.1002/mpo.2950040415
State	Published - 1978

Keywords

cis‐platinum
drug interaction
mannitol
renal toxicity

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Oncology
Cancer Research

Access to Document

10.1002/mpo.2950040415

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AU - Alberts, David S.

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AB - Cis‐diamminedichloroplatinum (II) cis‐platinum, 25–75 mg/m2, with 40 gm mannitol and fluid were given over 1–2 hours to 40 patients with no evidence of elevated serum creatinine levels. Cis‐platinum was administered every 28 days at a dose of 50mg/m2 to 22 patients, and 75mg/m2 to 6 patients. Patients received from one to eight courses of therapy with no change in their serum creatinine level. A safe, simple method of cis‐platinum administration has been achieved.

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KW - renal toxicity

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