Salivary gland basal cell and canalicular adenomas: Immunohistochemical demonstration of myoepithelial cell participation and morphogenetic considerations

Richard J. Zarbo, Anil P Rama Rao, Joseph A. Regezi, Allen M. Gown, Adnan T. Savera

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Objective. - To evaluate cellular composition of salivary gland adenomas using 3 monoclonal antibodies that recognize a smooth muscle phenotype confirmed to be sensitive for myoepithelial differentiation. Design. - Immunohistochemical evaluation of 25 salivary gland basal cell and canalicular adenomas. Setting. - Archival pathology material from the files of Henry Ford Hospital, Detroit, Mich, and the University of California at San Francisco. Results. - All basal cell adenoma variants exhibit some degree of myoepithelial cell participation with periductal, epithelioid, and spindled (stromal-like) morphologic structures. Only the canalicular adenomas, even if mixed with trabecular and solid patterns, are devoid of staining with these 3 antibodies, suggesting an adenoma composed exclusively of ductal luminal cells. Conclusions. - There is an overlapping histomorphologic and common cellular composition of the basal cell adenoma variants with other recognized adenomas, such as pleomorphic adenoma and myoepithelioma. Relative differentiation toward 3 cell phenotypes (ductal luminal, basal, and myoepithelial) and the character of extracellular matrix production in varying proportions by the neoplastic myoepithelial cells distinguishes the spectrum of salivary gland adenomas identified in current classification schemes.

Original languageEnglish (US)
Pages (from-to)401-405
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume124
Issue number3
StatePublished - 2000
Externally publishedYes

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Salivary Glands
Adenoma
Myoepithelioma
Phenotype
Pleomorphic Adenoma
San Francisco
Extracellular Matrix
Smooth Muscle
Monoclonal Antibodies
Pathology
Staining and Labeling
Antibodies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Salivary gland basal cell and canalicular adenomas : Immunohistochemical demonstration of myoepithelial cell participation and morphogenetic considerations. / Zarbo, Richard J.; Rama Rao, Anil P; Regezi, Joseph A.; Gown, Allen M.; Savera, Adnan T.

In: Archives of Pathology and Laboratory Medicine, Vol. 124, No. 3, 2000, p. 401-405.

Research output: Contribution to journalArticle

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