Salpingectomy as a means to reduce ovarian cancer risk

Mary B. Daly, Charles W. Dresher, Melinda S. Yates, Joanne M Jeter, Beth Y. Karlan, David S Alberts, Karen H. Lu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Bilateral salpingo-oophorectomy (BSO) has become the standard-of-care for risk reduction in women at hereditary risk of ovarian cancer. Although this procedure significantly decreases both the incidence of and mortality from ovarian cancer, it affects quality of life, and the premature cessation of ovarian function may have long-term health hazards. Recent advances in our understanding of the molecular pathways of ovarian cancer point to the fallopian tube epithelium as the origin of most high-grade serous cancers (HGSC). This evolving appreciation of the role of the fallopian tube in HGSC has led to the consideration of salpingectomy alone as an option for risk management, especially in premenopausal women. In addition, it is postulated that bilateral salpingectomy with ovarian retention (BSOR), may have a public health benefit for women undergoing benign gynecologic surgery. In this review, we provide the rationale for salpingectomy as an ovarian cancer risk reduction strategy.

Original languageEnglish (US)
Pages (from-to)342-348
Number of pages7
JournalCancer Prevention Research
Volume8
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

Salpingectomy
Ovarian Neoplasms
Fallopian Tubes
Risk Reduction Behavior
Gynecologic Surgical Procedures
Risk Management
Ovariectomy
Insurance Benefits
Standard of Care
Neoplasms
Epithelium
Public Health
Quality of Life
Mortality
Incidence
Health

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Salpingectomy as a means to reduce ovarian cancer risk. / Daly, Mary B.; Dresher, Charles W.; Yates, Melinda S.; Jeter, Joanne M; Karlan, Beth Y.; Alberts, David S; Lu, Karen H.

In: Cancer Prevention Research, Vol. 8, No. 5, 01.05.2015, p. 342-348.

Research output: Contribution to journalArticle

Daly, Mary B. ; Dresher, Charles W. ; Yates, Melinda S. ; Jeter, Joanne M ; Karlan, Beth Y. ; Alberts, David S ; Lu, Karen H. / Salpingectomy as a means to reduce ovarian cancer risk. In: Cancer Prevention Research. 2015 ; Vol. 8, No. 5. pp. 342-348.
@article{fc2478b6dd6e4862aaa72c737b97ca60,
title = "Salpingectomy as a means to reduce ovarian cancer risk",
abstract = "Bilateral salpingo-oophorectomy (BSO) has become the standard-of-care for risk reduction in women at hereditary risk of ovarian cancer. Although this procedure significantly decreases both the incidence of and mortality from ovarian cancer, it affects quality of life, and the premature cessation of ovarian function may have long-term health hazards. Recent advances in our understanding of the molecular pathways of ovarian cancer point to the fallopian tube epithelium as the origin of most high-grade serous cancers (HGSC). This evolving appreciation of the role of the fallopian tube in HGSC has led to the consideration of salpingectomy alone as an option for risk management, especially in premenopausal women. In addition, it is postulated that bilateral salpingectomy with ovarian retention (BSOR), may have a public health benefit for women undergoing benign gynecologic surgery. In this review, we provide the rationale for salpingectomy as an ovarian cancer risk reduction strategy.",
author = "Daly, {Mary B.} and Dresher, {Charles W.} and Yates, {Melinda S.} and Jeter, {Joanne M} and Karlan, {Beth Y.} and Alberts, {David S} and Lu, {Karen H.}",
year = "2015",
month = "5",
day = "1",
doi = "10.1158/1940-6207.CAPR-14-0293",
language = "English (US)",
volume = "8",
pages = "342--348",
journal = "Cancer Prevention Research",
issn = "1940-6207",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

TY - JOUR

T1 - Salpingectomy as a means to reduce ovarian cancer risk

AU - Daly, Mary B.

AU - Dresher, Charles W.

AU - Yates, Melinda S.

AU - Jeter, Joanne M

AU - Karlan, Beth Y.

AU - Alberts, David S

AU - Lu, Karen H.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Bilateral salpingo-oophorectomy (BSO) has become the standard-of-care for risk reduction in women at hereditary risk of ovarian cancer. Although this procedure significantly decreases both the incidence of and mortality from ovarian cancer, it affects quality of life, and the premature cessation of ovarian function may have long-term health hazards. Recent advances in our understanding of the molecular pathways of ovarian cancer point to the fallopian tube epithelium as the origin of most high-grade serous cancers (HGSC). This evolving appreciation of the role of the fallopian tube in HGSC has led to the consideration of salpingectomy alone as an option for risk management, especially in premenopausal women. In addition, it is postulated that bilateral salpingectomy with ovarian retention (BSOR), may have a public health benefit for women undergoing benign gynecologic surgery. In this review, we provide the rationale for salpingectomy as an ovarian cancer risk reduction strategy.

AB - Bilateral salpingo-oophorectomy (BSO) has become the standard-of-care for risk reduction in women at hereditary risk of ovarian cancer. Although this procedure significantly decreases both the incidence of and mortality from ovarian cancer, it affects quality of life, and the premature cessation of ovarian function may have long-term health hazards. Recent advances in our understanding of the molecular pathways of ovarian cancer point to the fallopian tube epithelium as the origin of most high-grade serous cancers (HGSC). This evolving appreciation of the role of the fallopian tube in HGSC has led to the consideration of salpingectomy alone as an option for risk management, especially in premenopausal women. In addition, it is postulated that bilateral salpingectomy with ovarian retention (BSOR), may have a public health benefit for women undergoing benign gynecologic surgery. In this review, we provide the rationale for salpingectomy as an ovarian cancer risk reduction strategy.

UR - http://www.scopus.com/inward/record.url?scp=84942519821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942519821&partnerID=8YFLogxK

U2 - 10.1158/1940-6207.CAPR-14-0293

DO - 10.1158/1940-6207.CAPR-14-0293

M3 - Article

C2 - 25586903

AN - SCOPUS:84942519821

VL - 8

SP - 342

EP - 348

JO - Cancer Prevention Research

JF - Cancer Prevention Research

SN - 1940-6207

IS - 5

ER -