Studies were conducted to determine if ISDN antagonizes the contractile responses to calcium of chemically-skinned aortic smooth muscle preparations. Isosorbide dinitrate relaxed intact aortic smooth muscle segments in a dose-dependent manner (0.01-100 μM). At all concentrations tested, ISDN was unable to relax triton-skinned smooth muscle preparations. However, the tension development of skinned preparations was inhibited by trifluoperazine (10 μM), a calmodulin antagonist. These results suggest that the relaxation of intact aortic smooth muscle preparations induced by ISDN is not related to an interference with calmodulin-dependent contractile events.
|Original language||English (US)|
|Number of pages||11|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - Jan 1 1986|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)