Satellite cell proliferation in response to pituitary hormones.

Ronald E Allen, M. V. Dodson, L. K. Boxhorn, S. L. Davis, K. L. Hossner

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Proliferation of rat skeletal muscle satellite cells was studied in vitro, and their ability to respond to a variety of protein hormones was examined, including: growth hormone, prolactin, luteinizing hormone, thyrotropin and fibroblast growth factor. All experiments were conducted in serum-free medium to avoid complicating interactions with serum constituents such as other hormones or binding proteins. Dose-response curves were constructed for each protein and encompassed the physiological range plus concentrations two to three orders of magnitude greater than the physiological range. Of the proteins examined, the only one shown to have the ability to directly stimulate satellite cell proliferation was fibroblast growth factor. None of the anterior pituitary protein hormones had the ability to interact directly with satellite cells to stimulate proliferation in vitro. Therefore, satellite cells seem to be selective in their response to protein hormones, and the classes identified thus far are hormones in the insulin-like growth factor family and fibroblast growth factor. These two classes of protein hormones are quite different and would not be expected to act through a common pathway. Consequently, we have proposed a dual regulatory system that may allow for local as well as systemic stimulation of satellite cells.

Original languageEnglish (US)
Pages (from-to)1596-1601
Number of pages6
JournalJournal of Animal Science
Volume62
Issue number6
StatePublished - Jun 1986
Externally publishedYes

Fingerprint

pituitary hormones
Pituitary Hormones
cell proliferation
Cell Proliferation
hormones
fibroblast growth factors
Hormones
Fibroblast Growth Factors
Proteins
proteins
Skeletal Muscle Satellite Cells
cells
Anterior Pituitary Hormones
anterior pituitary
thyrotropin
Serum-Free Culture Media
somatomedins
Somatomedins
Thyrotropin
luteinizing hormone

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Allen, R. E., Dodson, M. V., Boxhorn, L. K., Davis, S. L., & Hossner, K. L. (1986). Satellite cell proliferation in response to pituitary hormones. Journal of Animal Science, 62(6), 1596-1601.

Satellite cell proliferation in response to pituitary hormones. / Allen, Ronald E; Dodson, M. V.; Boxhorn, L. K.; Davis, S. L.; Hossner, K. L.

In: Journal of Animal Science, Vol. 62, No. 6, 06.1986, p. 1596-1601.

Research output: Contribution to journalArticle

Allen, RE, Dodson, MV, Boxhorn, LK, Davis, SL & Hossner, KL 1986, 'Satellite cell proliferation in response to pituitary hormones.', Journal of Animal Science, vol. 62, no. 6, pp. 1596-1601.
Allen RE, Dodson MV, Boxhorn LK, Davis SL, Hossner KL. Satellite cell proliferation in response to pituitary hormones. Journal of Animal Science. 1986 Jun;62(6):1596-1601.
Allen, Ronald E ; Dodson, M. V. ; Boxhorn, L. K. ; Davis, S. L. ; Hossner, K. L. / Satellite cell proliferation in response to pituitary hormones. In: Journal of Animal Science. 1986 ; Vol. 62, No. 6. pp. 1596-1601.
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