Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Giacomo Canesin, Annalisa Di Ruscio, Mailin Li, Simone Ummarino, Andreas Hedblom, Reeham Choudhury, Agnieszka Krzyzanowska, Eva Csizmadia, Macarena Palominos, Anna Stiehm, Alexander Ebralidze, Shao Yong Chen, Mahmoud A. Bassal, Ping Zhao, Emanuela Tolosano, Laurence Hurley, Anders Bjartell, Daniel G. Tenen, Barbara Wegiel

Research output: Contribution to journalArticle

Abstract

Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.

Original languageEnglish (US)
Article number108181
JournalCell Reports
Volume32
Issue number12
DOIs
StatePublished - Sep 22 2020

Keywords

  • c-myc
  • DNA G-quadruplexes
  • heme
  • heme oxygenase-1
  • hemopexin
  • metastases
  • prostate cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Canesin, G., Di Ruscio, A., Li, M., Ummarino, S., Hedblom, A., Choudhury, R., Krzyzanowska, A., Csizmadia, E., Palominos, M., Stiehm, A., Ebralidze, A., Chen, S. Y., Bassal, M. A., Zhao, P., Tolosano, E., Hurley, L., Bjartell, A., Tenen, D. G., & Wegiel, B. (2020). Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases. Cell Reports, 32(12), [108181]. https://doi.org/10.1016/j.celrep.2020.108181