Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Giacomo Canesin; Annalisa Di Ruscio; Mailin Li; Simone Ummarino; Andreas Hedblom; Reeham Choudhury; Agnieszka Krzyzanowska; Eva Csizmadia; Macarena Palominos; Anna Stiehm; Alexander Ebralidze; Shao Yong Chen; Mahmoud A. Bassal; Ping Zhao; Emanuela Tolosano; Laurence Hurley; Anders Bjartell; Daniel G. Tenen; Barbara Wegiel

doi:10.1016/j.celrep.2020.108181

Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Giacomo Canesin, Annalisa Di Ruscio, Mailin Li, Simone Ummarino, Andreas Hedblom, Reeham Choudhury, Agnieszka Krzyzanowska, Eva Csizmadia, Macarena Palominos, Anna Stiehm, Alexander Ebralidze, Shao Yong Chen, Mahmoud A. Bassal, Ping Zhao, Emanuela Tolosano, Laurence Hurley, Anders Bjartell, Daniel G. Tenen, Barbara Wegiel

Pharmacology and Toxicology

Research output: Contribution to journal › Article

Abstract

Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.

Original language	English (US)
Article number	108181
Journal	Cell Reports
Volume	32
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2020.108181
State	Published - Sep 22 2020

Keywords

c-myc
DNA G-quadruplexes
heme
heme oxygenase-1
hemopexin
metastases
prostate cancer

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Canesin, G., Di Ruscio, A., Li, M., Ummarino, S., Hedblom, A., Choudhury, R., Krzyzanowska, A., Csizmadia, E., Palominos, M., Stiehm, A., Ebralidze, A., Chen, S. Y., Bassal, M. A., Zhao, P., Tolosano, E., Hurley, L., Bjartell, A., Tenen, D. G., & Wegiel, B. (2020). Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases. Cell Reports, 32(12), [108181]. https://doi.org/10.1016/j.celrep.2020.108181

Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases. / Canesin, Giacomo; Di Ruscio, Annalisa; Li, Mailin; Ummarino, Simone; Hedblom, Andreas; Choudhury, Reeham; Krzyzanowska, Agnieszka; Csizmadia, Eva; Palominos, Macarena; Stiehm, Anna; Ebralidze, Alexander; Chen, Shao Yong; Bassal, Mahmoud A.; Zhao, Ping; Tolosano, Emanuela; Hurley, Laurence; Bjartell, Anders; Tenen, Daniel G.; Wegiel, Barbara.

In: Cell Reports, Vol. 32, No. 12, 108181, 22.09.2020.

Research output: Contribution to journal › Article

Canesin, G, Di Ruscio, A, Li, M, Ummarino, S, Hedblom, A, Choudhury, R, Krzyzanowska, A, Csizmadia, E, Palominos, M, Stiehm, A, Ebralidze, A, Chen, SY, Bassal, MA, Zhao, P, Tolosano, E, Hurley, L, Bjartell, A, Tenen, DG & Wegiel, B 2020, 'Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases', Cell Reports, vol. 32, no. 12, 108181. https://doi.org/10.1016/j.celrep.2020.108181

Canesin, Giacomo ; Di Ruscio, Annalisa ; Li, Mailin ; Ummarino, Simone ; Hedblom, Andreas ; Choudhury, Reeham ; Krzyzanowska, Agnieszka ; Csizmadia, Eva ; Palominos, Macarena ; Stiehm, Anna ; Ebralidze, Alexander ; Chen, Shao Yong ; Bassal, Mahmoud A. ; Zhao, Ping ; Tolosano, Emanuela ; Hurley, Laurence ; Bjartell, Anders ; Tenen, Daniel G. ; Wegiel, Barbara. / Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases. In: Cell Reports. 2020 ; Vol. 32, No. 12.

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abstract = "Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.",

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