Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.
- DNA G-quadruplexes
- heme oxygenase-1
- prostate cancer
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)