Sciatic function index, nerve conduction tests, muscle contraction, and axon morphometry as indicators of regeneration

Fuminori Kanaya, John C. Firrell, Warren C Breidenbach

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

The purpose of this study was to determine which parameters were the best measure of nerve regeneration, assuming that the sciatic functional index (SFI) represented the 'gold standard.' Three different sciatic functional indexes and 11 commonly used electrophysiologic and morphologic indicators of regeneration were all determined in 24 rats 12 weeks after one of three lesions was created in the sciatic nerve. With linear regression analysis, only fiber/axon diameter ratio (D/d) and myelin thickness/axon diameter ratio showed statistically significant correlations with sciatic functional index (r = 0.55 and 0.53, respectively). The other 11 parameters had poorer correlation. Therefore, if sciatic functional index is the best measure of comprehensive nerve function, then other parameters are not. It is probable that each parameter measures some different component of the regeneration process. A stepwise multiple linear regression analysis produced a model that included D/d, nerve conduction velocity, and nerve action potential amplitude that gave a slightly better correlation (r = 0.67). The relatively poor correlation between sciatic functional index and the other parameters of nerve function indicates that all nerve regeneration studies must be interpreted carefully before comparisons are made. Furthermore, the best measure of nerve function remains unproved or undiscovered in the experimental animal.

Original languageEnglish (US)
Pages (from-to)1264-1274
Number of pages11
JournalPlastic and Reconstructive Surgery
Volume98
Issue number7
StatePublished - Dec 1996
Externally publishedYes

Fingerprint

Nerve Regeneration
Neural Conduction
Muscle Contraction
Axons
Regeneration
Linear Models
Regression Analysis
Sciatic Nerve
Myelin Sheath
Action Potentials

ASJC Scopus subject areas

  • Surgery

Cite this

Sciatic function index, nerve conduction tests, muscle contraction, and axon morphometry as indicators of regeneration. / Kanaya, Fuminori; Firrell, John C.; Breidenbach, Warren C.

In: Plastic and Reconstructive Surgery, Vol. 98, No. 7, 12.1996, p. 1264-1274.

Research output: Contribution to journalArticle

@article{8dd34100e8cf4c5d9227f751b33ba6fa,
title = "Sciatic function index, nerve conduction tests, muscle contraction, and axon morphometry as indicators of regeneration",
abstract = "The purpose of this study was to determine which parameters were the best measure of nerve regeneration, assuming that the sciatic functional index (SFI) represented the 'gold standard.' Three different sciatic functional indexes and 11 commonly used electrophysiologic and morphologic indicators of regeneration were all determined in 24 rats 12 weeks after one of three lesions was created in the sciatic nerve. With linear regression analysis, only fiber/axon diameter ratio (D/d) and myelin thickness/axon diameter ratio showed statistically significant correlations with sciatic functional index (r = 0.55 and 0.53, respectively). The other 11 parameters had poorer correlation. Therefore, if sciatic functional index is the best measure of comprehensive nerve function, then other parameters are not. It is probable that each parameter measures some different component of the regeneration process. A stepwise multiple linear regression analysis produced a model that included D/d, nerve conduction velocity, and nerve action potential amplitude that gave a slightly better correlation (r = 0.67). The relatively poor correlation between sciatic functional index and the other parameters of nerve function indicates that all nerve regeneration studies must be interpreted carefully before comparisons are made. Furthermore, the best measure of nerve function remains unproved or undiscovered in the experimental animal.",
author = "Fuminori Kanaya and Firrell, {John C.} and Breidenbach, {Warren C}",
year = "1996",
month = "12",
language = "English (US)",
volume = "98",
pages = "1264--1274",
journal = "Plastic and Reconstructive Surgery",
issn = "0032-1052",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Sciatic function index, nerve conduction tests, muscle contraction, and axon morphometry as indicators of regeneration

AU - Kanaya, Fuminori

AU - Firrell, John C.

AU - Breidenbach, Warren C

PY - 1996/12

Y1 - 1996/12

N2 - The purpose of this study was to determine which parameters were the best measure of nerve regeneration, assuming that the sciatic functional index (SFI) represented the 'gold standard.' Three different sciatic functional indexes and 11 commonly used electrophysiologic and morphologic indicators of regeneration were all determined in 24 rats 12 weeks after one of three lesions was created in the sciatic nerve. With linear regression analysis, only fiber/axon diameter ratio (D/d) and myelin thickness/axon diameter ratio showed statistically significant correlations with sciatic functional index (r = 0.55 and 0.53, respectively). The other 11 parameters had poorer correlation. Therefore, if sciatic functional index is the best measure of comprehensive nerve function, then other parameters are not. It is probable that each parameter measures some different component of the regeneration process. A stepwise multiple linear regression analysis produced a model that included D/d, nerve conduction velocity, and nerve action potential amplitude that gave a slightly better correlation (r = 0.67). The relatively poor correlation between sciatic functional index and the other parameters of nerve function indicates that all nerve regeneration studies must be interpreted carefully before comparisons are made. Furthermore, the best measure of nerve function remains unproved or undiscovered in the experimental animal.

AB - The purpose of this study was to determine which parameters were the best measure of nerve regeneration, assuming that the sciatic functional index (SFI) represented the 'gold standard.' Three different sciatic functional indexes and 11 commonly used electrophysiologic and morphologic indicators of regeneration were all determined in 24 rats 12 weeks after one of three lesions was created in the sciatic nerve. With linear regression analysis, only fiber/axon diameter ratio (D/d) and myelin thickness/axon diameter ratio showed statistically significant correlations with sciatic functional index (r = 0.55 and 0.53, respectively). The other 11 parameters had poorer correlation. Therefore, if sciatic functional index is the best measure of comprehensive nerve function, then other parameters are not. It is probable that each parameter measures some different component of the regeneration process. A stepwise multiple linear regression analysis produced a model that included D/d, nerve conduction velocity, and nerve action potential amplitude that gave a slightly better correlation (r = 0.67). The relatively poor correlation between sciatic functional index and the other parameters of nerve function indicates that all nerve regeneration studies must be interpreted carefully before comparisons are made. Furthermore, the best measure of nerve function remains unproved or undiscovered in the experimental animal.

UR - http://www.scopus.com/inward/record.url?scp=0029904013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029904013&partnerID=8YFLogxK

M3 - Article

C2 - 8942915

AN - SCOPUS:0029904013

VL - 98

SP - 1264

EP - 1274

JO - Plastic and Reconstructive Surgery

JF - Plastic and Reconstructive Surgery

SN - 0032-1052

IS - 7

ER -