Science to practice: How can cardiac MR imaging help guide development of gene therapy for treatment of coronary heart disease?

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Jacquier et al have shown with magnetic resonance (MR) imaging that therapy with direct intracardiac injection of vascular endothelial growth factor gene (VEGF) improves myocardial function in a model of myocardial infarction in swine. Jacquier and colleagues used MR imaging to measure left ventricular (LV) function and strain and showed that animals treated with gene therapy had stable ejection fraction whereas control animals deteriorated.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalRadiology
Volume245
Issue number1
DOIs
StatePublished - Oct 2007

Fingerprint

Genetic Therapy
Coronary Disease
Magnetic Resonance Imaging
Left Ventricular Function
Vascular Endothelial Growth Factor A
Swine
Myocardial Infarction
Injections
Therapeutics
Genes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

@article{06d8d165bdf04833b34d7e856b169117,
title = "Science to practice: How can cardiac MR imaging help guide development of gene therapy for treatment of coronary heart disease?",
abstract = "Jacquier et al have shown with magnetic resonance (MR) imaging that therapy with direct intracardiac injection of vascular endothelial growth factor gene (VEGF) improves myocardial function in a model of myocardial infarction in swine. Jacquier and colleagues used MR imaging to measure left ventricular (LV) function and strain and showed that animals treated with gene therapy had stable ejection fraction whereas control animals deteriorated.",
author = "Unger, {Evan C}",
year = "2007",
month = "10",
doi = "10.1148/radiol.2451070872",
language = "English (US)",
volume = "245",
pages = "1--2",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "1",

}

TY - JOUR

T1 - Science to practice

T2 - How can cardiac MR imaging help guide development of gene therapy for treatment of coronary heart disease?

AU - Unger, Evan C

PY - 2007/10

Y1 - 2007/10

N2 - Jacquier et al have shown with magnetic resonance (MR) imaging that therapy with direct intracardiac injection of vascular endothelial growth factor gene (VEGF) improves myocardial function in a model of myocardial infarction in swine. Jacquier and colleagues used MR imaging to measure left ventricular (LV) function and strain and showed that animals treated with gene therapy had stable ejection fraction whereas control animals deteriorated.

AB - Jacquier et al have shown with magnetic resonance (MR) imaging that therapy with direct intracardiac injection of vascular endothelial growth factor gene (VEGF) improves myocardial function in a model of myocardial infarction in swine. Jacquier and colleagues used MR imaging to measure left ventricular (LV) function and strain and showed that animals treated with gene therapy had stable ejection fraction whereas control animals deteriorated.

UR - http://www.scopus.com/inward/record.url?scp=34548664160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548664160&partnerID=8YFLogxK

U2 - 10.1148/radiol.2451070872

DO - 10.1148/radiol.2451070872

M3 - Article

C2 - 17885172

AN - SCOPUS:34548664160

VL - 245

SP - 1

EP - 2

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 1

ER -