Science to practice: Will randomized prospective clinical trials be necessary for RF Ablation of large liver tumors with liposomal doxorubicin?

Research output: Contribution to journalArticle

Abstract

Summary: In this issue of Radiology, Solazzo et al (1) elucidate the mechanisms involved in cell death and cell repair at radiofrequency (RF) ablation and at combination therapy with RF ablation and the chemotherapeutic drug liposomal doxorubicin in an animal model. They show that combination therapy results in increased oxidative and nitrative stress, as well as DNA damage, and that these cellular changes are responsible for the increase in the zone of necrosis attained with combination therapy.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalRadiology
Volume255
Issue number1
DOIs
StatePublished - Apr 2010

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Randomized Controlled Trials
Liver
Neoplasms
Radiology
DNA Damage
Oxidative Stress
Cell Death
Necrosis
Therapeutics
Animal Models
Pharmaceutical Preparations
liposomal doxorubicin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "Summary: In this issue of Radiology, Solazzo et al (1) elucidate the mechanisms involved in cell death and cell repair at radiofrequency (RF) ablation and at combination therapy with RF ablation and the chemotherapeutic drug liposomal doxorubicin in an animal model. They show that combination therapy results in increased oxidative and nitrative stress, as well as DNA damage, and that these cellular changes are responsible for the increase in the zone of necrosis attained with combination therapy.",
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