SCRAM: A scoring and ranking system for persistent, bioaccumulative, and toxic substances for the North American Great Lakes: Part III. Acute and subchronic or chronic toxicity

Erin M. Snyder, Shane A. Snyder, John P. Giesy, Shari A. Blonde, Gary K. Hurlburt, Cheryl L. Summer, Rachel R. Mitchell, Dennis M. Bush

Research output: Contribution to journalShort survey

10 Scopus citations

Abstract

In Part I of this series (Snyder et al., 1999a), the Chemical Scoring and Ranking Assessment Model (SCRAM) was introduced. This system produces scores for chemicals based on their bioaccumulation potential, environmental persistence, and toxicity. In Part II, scoring of the potential for a chemical to persist in the environment and bioaccumulate was described (Snyder et al., 1999b). In Part III, scoring of chemical toxicity is discussed, including definitions and descriptions of effects that are scored, specific scoring instructions, the basis for the criteria and scores, and specific conditions or concerns regarding the types of data used for scoring. A score for each chemical screened is determined from available test data from acute or subchronic and chronic toxicity tests conducted on aquatic and terrestrial organisms. Subchronic and chronic human health effects, including carcinogenicity, are also considered. Part IV includes an evaluation of the performance of the scoring and ranking system (Snyder et al., 1999c).

Original languageEnglish (US)
Number of pages1
JournalEnvironmental Science and Pollution Research
Volume7
Issue number3
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Acute toxicity
  • Bioaccumulation
  • Chemical scoring and ranking
  • Chronic toxicity
  • Hazard
  • North American Great Lakes
  • Persistence
  • Priority pollutants
  • SCRAM (Chemical Scoring and Ranking Assessment Model)
  • Uncertainty
  • Water pollution

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution
  • Health, Toxicology and Mutagenesis

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