Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi

Sergio Martínez-Luis, Lilia Cherigo, Sarah Higginbotham, Anne E Arnold, Carmenza Spadafora, Alicia Ibañez, William H. Gerwick, Luis Cubilla-Rios

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Many compounds produced by fungi have relevant pharmaceutical applications. The purpose of this study was to collect and isolate entophytic fungi from different regions of Panama and then to test their potential therapeutic activities against Leishmania donovani, Plasmodium falciparum, and Trypanosoma cruzi as well as their anticancer activities in MCF-7 cells. Of the 25 fungal isolates obtained, ten of them had good anti-parasitic potential, showing selective activity against L. donovani; four had significant anti-malarial activity; and three inhibited the growth of T. cruzi. Anticancer activity was demonstrated in four isolates. Of the active isolates, Edenia sp. strain F0755, Xylaria sp. strain F1220, Aspergillus sp. strain F1544, Mycoleptodiscus sp. strain F0194, Phomopsis sp. strain F1566, Pycnoporus sp. strain F0305, and Diaporthe sp. strain F1647 showed the most promise based on their selective bioactivity and lack of toxicity in the assays.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalInternational Microbiology
Volume14
Issue number2
DOIs
StatePublished - Jun 2011

Fingerprint

Antiparasitic Agents
Leishmania donovani
Trypanosoma cruzi
Pycnoporus
Fungi
Panama
MCF-7 Cells
Antimalarials
Aspergillus
Plasmodium falciparum
Growth
Pharmaceutical Preparations
In Vitro Techniques
Therapeutics

Keywords

  • Anticancer activity
  • Chagas's disease
  • Endophytic fungi
  • Leishmania
  • Malaria

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Martínez-Luis, S., Cherigo, L., Higginbotham, S., Arnold, A. E., Spadafora, C., Ibañez, A., ... Cubilla-Rios, L. (2011). Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi. International Microbiology, 14(2), 95-102. https://doi.org/10.2436/20.1501.01.139

Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi. / Martínez-Luis, Sergio; Cherigo, Lilia; Higginbotham, Sarah; Arnold, Anne E; Spadafora, Carmenza; Ibañez, Alicia; Gerwick, William H.; Cubilla-Rios, Luis.

In: International Microbiology, Vol. 14, No. 2, 06.2011, p. 95-102.

Research output: Contribution to journalArticle

Martínez-Luis, S, Cherigo, L, Higginbotham, S, Arnold, AE, Spadafora, C, Ibañez, A, Gerwick, WH & Cubilla-Rios, L 2011, 'Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi', International Microbiology, vol. 14, no. 2, pp. 95-102. https://doi.org/10.2436/20.1501.01.139
Martínez-Luis, Sergio ; Cherigo, Lilia ; Higginbotham, Sarah ; Arnold, Anne E ; Spadafora, Carmenza ; Ibañez, Alicia ; Gerwick, William H. ; Cubilla-Rios, Luis. / Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi. In: International Microbiology. 2011 ; Vol. 14, No. 2. pp. 95-102.
@article{6a849c8d9c584897ba52c245cdf9c30a,
title = "Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi",
abstract = "Many compounds produced by fungi have relevant pharmaceutical applications. The purpose of this study was to collect and isolate entophytic fungi from different regions of Panama and then to test their potential therapeutic activities against Leishmania donovani, Plasmodium falciparum, and Trypanosoma cruzi as well as their anticancer activities in MCF-7 cells. Of the 25 fungal isolates obtained, ten of them had good anti-parasitic potential, showing selective activity against L. donovani; four had significant anti-malarial activity; and three inhibited the growth of T. cruzi. Anticancer activity was demonstrated in four isolates. Of the active isolates, Edenia sp. strain F0755, Xylaria sp. strain F1220, Aspergillus sp. strain F1544, Mycoleptodiscus sp. strain F0194, Phomopsis sp. strain F1566, Pycnoporus sp. strain F0305, and Diaporthe sp. strain F1647 showed the most promise based on their selective bioactivity and lack of toxicity in the assays.",
keywords = "Anticancer activity, Chagas's disease, Endophytic fungi, Leishmania, Malaria",
author = "Sergio Mart{\'i}nez-Luis and Lilia Cherigo and Sarah Higginbotham and Arnold, {Anne E} and Carmenza Spadafora and Alicia Iba{\~n}ez and Gerwick, {William H.} and Luis Cubilla-Rios",
year = "2011",
month = "6",
doi = "10.2436/20.1501.01.139",
language = "English (US)",
volume = "14",
pages = "95--102",
journal = "International Microbiology",
issn = "1139-6709",
publisher = "Sociedad Espanola de Microbiologia",
number = "2",

}

TY - JOUR

T1 - Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi

AU - Martínez-Luis, Sergio

AU - Cherigo, Lilia

AU - Higginbotham, Sarah

AU - Arnold, Anne E

AU - Spadafora, Carmenza

AU - Ibañez, Alicia

AU - Gerwick, William H.

AU - Cubilla-Rios, Luis

PY - 2011/6

Y1 - 2011/6

N2 - Many compounds produced by fungi have relevant pharmaceutical applications. The purpose of this study was to collect and isolate entophytic fungi from different regions of Panama and then to test their potential therapeutic activities against Leishmania donovani, Plasmodium falciparum, and Trypanosoma cruzi as well as their anticancer activities in MCF-7 cells. Of the 25 fungal isolates obtained, ten of them had good anti-parasitic potential, showing selective activity against L. donovani; four had significant anti-malarial activity; and three inhibited the growth of T. cruzi. Anticancer activity was demonstrated in four isolates. Of the active isolates, Edenia sp. strain F0755, Xylaria sp. strain F1220, Aspergillus sp. strain F1544, Mycoleptodiscus sp. strain F0194, Phomopsis sp. strain F1566, Pycnoporus sp. strain F0305, and Diaporthe sp. strain F1647 showed the most promise based on their selective bioactivity and lack of toxicity in the assays.

AB - Many compounds produced by fungi have relevant pharmaceutical applications. The purpose of this study was to collect and isolate entophytic fungi from different regions of Panama and then to test their potential therapeutic activities against Leishmania donovani, Plasmodium falciparum, and Trypanosoma cruzi as well as their anticancer activities in MCF-7 cells. Of the 25 fungal isolates obtained, ten of them had good anti-parasitic potential, showing selective activity against L. donovani; four had significant anti-malarial activity; and three inhibited the growth of T. cruzi. Anticancer activity was demonstrated in four isolates. Of the active isolates, Edenia sp. strain F0755, Xylaria sp. strain F1220, Aspergillus sp. strain F1544, Mycoleptodiscus sp. strain F0194, Phomopsis sp. strain F1566, Pycnoporus sp. strain F0305, and Diaporthe sp. strain F1647 showed the most promise based on their selective bioactivity and lack of toxicity in the assays.

KW - Anticancer activity

KW - Chagas's disease

KW - Endophytic fungi

KW - Leishmania

KW - Malaria

UR - http://www.scopus.com/inward/record.url?scp=80054945934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054945934&partnerID=8YFLogxK

U2 - 10.2436/20.1501.01.139

DO - 10.2436/20.1501.01.139

M3 - Article

VL - 14

SP - 95

EP - 102

JO - International Microbiology

JF - International Microbiology

SN - 1139-6709

IS - 2

ER -