Seasonal risk factors for asthma exacerbations among inner-city children

Stephen J. Teach, Peter J. Gergen, Stanley J. Szefler, Herman E. Mitchell, Agustin Calatroni, Jeremy Wildfire, Gordon R. Bloomberg, Carolyn M. Kercsmar, Andrew H. Liu, Melanie M. Makhija, Elizabeth Matsui, Wayne J Morgan, George O'Connor, William W. Busse

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72 Citations (Scopus)

Abstract

Background Asthma exacerbations remain common, even in children and adolescents, despite optimal medical management. Identification of host risk factors for exacerbations is incomplete, particularly for seasonal episodes. Objective We sought to define host risk factors for asthma exacerbations unique to their season of occurrence. Methods This is a retrospective analysis of patients aged 6 to 20 years who comprised the control groups of the Asthma Control Evaluation study and the Inner City Anti-IgE Therapy for Asthma study. Univariate and multivariate models were constructed to determine whether patients' demographic and historical factors, allergic sensitization, fraction of exhaled nitric oxide values, spirometric measurements, asthma control, and treatment requirements were associated with seasonal exacerbations. Results The analysis included 400 patients (54.5% male; 59.0% African American; median age, 13 years). Exacerbations occurred in 37.5% of participants over the periods of observation and were most common in the fall (28.8% of participants). In univariate analysis impaired pulmonary function was significantly associated with greater odds of exacerbations for all seasons, as was an exacerbation in the previous season for all seasons except spring. In multivariate analysis exacerbation in the previous season was the strongest predictor in fall and winter, whereas a higher requirement for inhaled corticosteroids was the strongest predictor in spring and summer. The multivariate models had the best predictive power for fall exacerbations (30.5% variance attributed). Conclusions Among a large cohort of inner-city children with asthma, patients' risk factors for exacerbation vary by season. Thus information on individual patients might be beneficial in strategies to prevent these seasonal events.

Original languageEnglish (US)
Pages (from-to)1465-1473e5
JournalJournal of Allergy and Clinical Immunology
Volume135
Issue number6
DOIs
StatePublished - Jun 1 2015

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Asthma
African Americans
Adrenal Cortex Hormones
Nitric Oxide
Multivariate Analysis
Observation
Demography
Lung
Control Groups
Therapeutics

Keywords

  • allergy
  • Asthma
  • asthma exacerbations
  • biomarkers
  • eosinophils
  • exhaled nitric oxide
  • IgE
  • pulmonary function
  • seasons

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Teach, S. J., Gergen, P. J., Szefler, S. J., Mitchell, H. E., Calatroni, A., Wildfire, J., ... Busse, W. W. (2015). Seasonal risk factors for asthma exacerbations among inner-city children. Journal of Allergy and Clinical Immunology, 135(6), 1465-1473e5. https://doi.org/10.1016/j.jaci.2014.12.1942

Seasonal risk factors for asthma exacerbations among inner-city children. / Teach, Stephen J.; Gergen, Peter J.; Szefler, Stanley J.; Mitchell, Herman E.; Calatroni, Agustin; Wildfire, Jeremy; Bloomberg, Gordon R.; Kercsmar, Carolyn M.; Liu, Andrew H.; Makhija, Melanie M.; Matsui, Elizabeth; Morgan, Wayne J; O'Connor, George; Busse, William W.

In: Journal of Allergy and Clinical Immunology, Vol. 135, No. 6, 01.06.2015, p. 1465-1473e5.

Research output: Contribution to journalArticle

Teach, SJ, Gergen, PJ, Szefler, SJ, Mitchell, HE, Calatroni, A, Wildfire, J, Bloomberg, GR, Kercsmar, CM, Liu, AH, Makhija, MM, Matsui, E, Morgan, WJ, O'Connor, G & Busse, WW 2015, 'Seasonal risk factors for asthma exacerbations among inner-city children', Journal of Allergy and Clinical Immunology, vol. 135, no. 6, pp. 1465-1473e5. https://doi.org/10.1016/j.jaci.2014.12.1942
Teach SJ, Gergen PJ, Szefler SJ, Mitchell HE, Calatroni A, Wildfire J et al. Seasonal risk factors for asthma exacerbations among inner-city children. Journal of Allergy and Clinical Immunology. 2015 Jun 1;135(6):1465-1473e5. https://doi.org/10.1016/j.jaci.2014.12.1942
Teach, Stephen J. ; Gergen, Peter J. ; Szefler, Stanley J. ; Mitchell, Herman E. ; Calatroni, Agustin ; Wildfire, Jeremy ; Bloomberg, Gordon R. ; Kercsmar, Carolyn M. ; Liu, Andrew H. ; Makhija, Melanie M. ; Matsui, Elizabeth ; Morgan, Wayne J ; O'Connor, George ; Busse, William W. / Seasonal risk factors for asthma exacerbations among inner-city children. In: Journal of Allergy and Clinical Immunology. 2015 ; Vol. 135, No. 6. pp. 1465-1473e5.
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abstract = "Background Asthma exacerbations remain common, even in children and adolescents, despite optimal medical management. Identification of host risk factors for exacerbations is incomplete, particularly for seasonal episodes. Objective We sought to define host risk factors for asthma exacerbations unique to their season of occurrence. Methods This is a retrospective analysis of patients aged 6 to 20 years who comprised the control groups of the Asthma Control Evaluation study and the Inner City Anti-IgE Therapy for Asthma study. Univariate and multivariate models were constructed to determine whether patients' demographic and historical factors, allergic sensitization, fraction of exhaled nitric oxide values, spirometric measurements, asthma control, and treatment requirements were associated with seasonal exacerbations. Results The analysis included 400 patients (54.5{\%} male; 59.0{\%} African American; median age, 13 years). Exacerbations occurred in 37.5{\%} of participants over the periods of observation and were most common in the fall (28.8{\%} of participants). In univariate analysis impaired pulmonary function was significantly associated with greater odds of exacerbations for all seasons, as was an exacerbation in the previous season for all seasons except spring. In multivariate analysis exacerbation in the previous season was the strongest predictor in fall and winter, whereas a higher requirement for inhaled corticosteroids was the strongest predictor in spring and summer. The multivariate models had the best predictive power for fall exacerbations (30.5{\%} variance attributed). Conclusions Among a large cohort of inner-city children with asthma, patients' risk factors for exacerbation vary by season. Thus information on individual patients might be beneficial in strategies to prevent these seasonal events.",
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AU - Gergen, Peter J.

AU - Szefler, Stanley J.

AU - Mitchell, Herman E.

AU - Calatroni, Agustin

AU - Wildfire, Jeremy

AU - Bloomberg, Gordon R.

AU - Kercsmar, Carolyn M.

AU - Liu, Andrew H.

AU - Makhija, Melanie M.

AU - Matsui, Elizabeth

AU - Morgan, Wayne J

AU - O'Connor, George

AU - Busse, William W.

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N2 - Background Asthma exacerbations remain common, even in children and adolescents, despite optimal medical management. Identification of host risk factors for exacerbations is incomplete, particularly for seasonal episodes. Objective We sought to define host risk factors for asthma exacerbations unique to their season of occurrence. Methods This is a retrospective analysis of patients aged 6 to 20 years who comprised the control groups of the Asthma Control Evaluation study and the Inner City Anti-IgE Therapy for Asthma study. Univariate and multivariate models were constructed to determine whether patients' demographic and historical factors, allergic sensitization, fraction of exhaled nitric oxide values, spirometric measurements, asthma control, and treatment requirements were associated with seasonal exacerbations. Results The analysis included 400 patients (54.5% male; 59.0% African American; median age, 13 years). Exacerbations occurred in 37.5% of participants over the periods of observation and were most common in the fall (28.8% of participants). In univariate analysis impaired pulmonary function was significantly associated with greater odds of exacerbations for all seasons, as was an exacerbation in the previous season for all seasons except spring. In multivariate analysis exacerbation in the previous season was the strongest predictor in fall and winter, whereas a higher requirement for inhaled corticosteroids was the strongest predictor in spring and summer. The multivariate models had the best predictive power for fall exacerbations (30.5% variance attributed). Conclusions Among a large cohort of inner-city children with asthma, patients' risk factors for exacerbation vary by season. Thus information on individual patients might be beneficial in strategies to prevent these seasonal events.

AB - Background Asthma exacerbations remain common, even in children and adolescents, despite optimal medical management. Identification of host risk factors for exacerbations is incomplete, particularly for seasonal episodes. Objective We sought to define host risk factors for asthma exacerbations unique to their season of occurrence. Methods This is a retrospective analysis of patients aged 6 to 20 years who comprised the control groups of the Asthma Control Evaluation study and the Inner City Anti-IgE Therapy for Asthma study. Univariate and multivariate models were constructed to determine whether patients' demographic and historical factors, allergic sensitization, fraction of exhaled nitric oxide values, spirometric measurements, asthma control, and treatment requirements were associated with seasonal exacerbations. Results The analysis included 400 patients (54.5% male; 59.0% African American; median age, 13 years). Exacerbations occurred in 37.5% of participants over the periods of observation and were most common in the fall (28.8% of participants). In univariate analysis impaired pulmonary function was significantly associated with greater odds of exacerbations for all seasons, as was an exacerbation in the previous season for all seasons except spring. In multivariate analysis exacerbation in the previous season was the strongest predictor in fall and winter, whereas a higher requirement for inhaled corticosteroids was the strongest predictor in spring and summer. The multivariate models had the best predictive power for fall exacerbations (30.5% variance attributed). Conclusions Among a large cohort of inner-city children with asthma, patients' risk factors for exacerbation vary by season. Thus information on individual patients might be beneficial in strategies to prevent these seasonal events.

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KW - Asthma

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KW - biomarkers

KW - eosinophils

KW - exhaled nitric oxide

KW - IgE

KW - pulmonary function

KW - seasons

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