Secondary Conditions among Males with Duchenne or Becker Muscular Dystrophy

Rebecca Latimer, Natalie Street, Kristin Caspers Conway, Kathy James, Christopher Cunniff, Joyce Oleszek, Deborah Fox, Emma Ciafaloni, Christina Westfield, Pangaja Paramsothy

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Duchenne and Becker muscular dystrophy are X-linked neuromuscular disorders characterized by progressive muscle degeneration. Despite the involvement of multiple systems, secondary conditions among affected males have not been comprehensively described. Two hundred nine caregivers of affected males (aged 3-31 years) identified by the Muscular Dystrophy Surveillance, Tracking, and Research Network completed a mailed survey that included questions about secondary conditions impacting multiple body functions. The 5 most commonly reported conditions in males with Duchenne were cognitive deficits (38.4%), constipation (31.7%), anxiety (29.3%), depression (27.4%), and obesity (19.5%). Higher frequencies of anxiety, depression, and kidney stones were found among nonambulatory males compared to ambulatory males. Attention-deficit hyperactivity disorder (ADHD) was more common in ambulatory than nonambulatory males. These data support clinical care recommendations for monitoring of patients with Duchenne or Becker muscular dystrophy by a multidisciplinary team to prevent and treat conditions that may be secondary to the diagnosis.

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalJournal of Child Neurology
Volume32
Issue number7
DOIs
StatePublished - Jun 1 2017

Keywords

  • Becker
  • Duchenne
  • comorbidities
  • muscular dystrophy
  • secondary conditions

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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    Latimer, R., Street, N., Conway, K. C., James, K., Cunniff, C., Oleszek, J., Fox, D., Ciafaloni, E., Westfield, C., & Paramsothy, P. (2017). Secondary Conditions among Males with Duchenne or Becker Muscular Dystrophy. Journal of Child Neurology, 32(7), 663-670. https://doi.org/10.1177/0883073817701368