Sedative dosing of propofol for treatment of migraine headache in the emergency department: A case series

Jarrod Mosier, Grant Roper, Daniel Hays, John A Guisto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Introduction: Migraine headaches requiring an emergency department visit due to failed outpatient rescue therapy present a significant challenge in terms of length of stay (LOS) and financial costs. Propofol therapy may be effective at pain reduction and reduce that length of stay given its pharmacokinetic properties as a short acting intravenous sedative anesthetic and pharmacodynamics on GABA mediated chloride flux. Methods: Case series of 4 patients presenting to an urban academic medical center with migraine headache failing outpatient therapy. Each patient was given a sedation dose (1 mg/kg) of propofol under standard procedural sedation precautions. Results: Each of the 4 patients experienced dramatic reductions or complete resolution of headache severity. LOS for 3 of the 4 patients was 50% less than the average LOS for patients with similar chief complaints to our emergency department. 1 patient required further treatment with standard therapy but had a significant reduction in pain and a shorter LOS. There were no episodes of hypotension, hypoxia, or apnea during the sedations. Conclusion: In this small case series, sedation dose propofol appears to be effective and safe for the treatment of refractory migraines, and may result in a reduced LOS.

Original languageEnglish (US)
Pages (from-to)646-649
Number of pages4
JournalWestern Journal of Emergency Medicine
Volume14
Issue number6
DOIs
StatePublished - 2013

Fingerprint

Propofol
Hypnotics and Sedatives
Migraine Disorders
Hospital Emergency Service
Length of Stay
Outpatients
Therapeutics
Intravenous Anesthetics
Pain
Apnea
Hypotension
gamma-Aminobutyric Acid
Headache
Chlorides
Pharmacokinetics
Costs and Cost Analysis

Keywords

  • Emergency Medicine
  • Migraine
  • Propofol

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Sedative dosing of propofol for treatment of migraine headache in the emergency department : A case series. / Mosier, Jarrod; Roper, Grant; Hays, Daniel; Guisto, John A.

In: Western Journal of Emergency Medicine, Vol. 14, No. 6, 2013, p. 646-649.

Research output: Contribution to journalArticle

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