Segmental arterial mediolysis and fibromuscular dysplasia: What comes first, the chicken or the egg?

E. Tyler Hall, Blake A. Gibson, Charles T Hennemeyer, Paola Devis, Stacey Black, Brandon T. Larsen

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Segmental arterial mediolysis (SAM) is a rare vasculopathy characterized by lysis of the outer media in splanchnic arteries and formation of dissecting pseudoaneurysms that may spontaneously rupture, leading to massive and often fatal intraabdominal hemorrhage. The pathogenesis of SAM is poorly understood. Healed SAM lesions closely resemble fibromuscular dysplasia (FMD), leading some authors to postulate that SAM represents a precursor to FMD despite distinct clinical differences between these two disorders. Herein, we present a 61-year-old woman with fatal SAM who showed histologic features in her aorta suggesting the opposite pathogenetic relationship, with an unclassified "FMD-like" arteriopathy preceding development of SAM.

Original languageEnglish (US)
Pages (from-to)113-115
Number of pages3
JournalCardiovascular Pathology
Volume25
Issue number2
DOIs
StatePublished - Mar 1 2016

Keywords

  • Fibromuscular dysplasia
  • Segmental arterial mediolysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pathology and Forensic Medicine

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