Selective cell proliferation can be controlled with CPC particle coatings

J. A. Szivek, D. S. Margolis, A. B. Schnepp, W. A. Grana, S. K. Williams

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

To develop implantable, engineered, cartilage constructs supported by a scaffold, techniques to encourage rapid tissue growth into, and on the scaffold are essential. Preliminary studies indicated that human endothelial cells proliferated at different rates on different calcium phosphate ceramic (CPC) particles. Judicious selection of particles may encourage specific cell proliferation, leading to an ordered growth of tissues for angiogenesis, osteogenesis, and chondrogenesis. The goal of this study was to identify CPC surfaces that encourage bone and vascular cell growth, and other surfaces that support chondrocyte growth while inhibiting proliferation of vascular cells. Differences in bone and vascular cell proliferation were observed when using epoxy without embedded CPCs to encourage bone cells, and when three CPCs were tested, which encouraged vascular cell proliferation. One of these (CPC 7) also substantially depressed cartilage cell proliferation. Only one small-diameter crystalline CPC (CPC 2) supported rapid chondrocyte proliferation, and maintained the cartilage cell phenotype.

Original languageEnglish (US)
Pages (from-to)939-947
Number of pages9
JournalJournal of Biomedical Materials Research - Part A
Volume81
Issue number4
DOIs
StatePublished - Jun 15 2007

Keywords

  • Chondrocytes
  • Endothelial cells
  • Hydroxyapatite
  • Osteoblasts
  • Proteoglycan

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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