Selective modulation of morphine antinociception, but not development of tolerance, by δ receptor agonists

Jiang Qi, Henry I. Mosberg, Frank Porreca

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Co-administration of δ opioid agonists at doses which do not produce measurable antinociception were demonstrated to produce an increase in the antinociceptive potency of morphine in the mouse tail-flick test. In contrast, co-administration of equi-antinociceptive combinations of a δ agonist plus morphine for three days resulted in the development of less tolerance to morphine antinociceptive actions. The data indicate that while acute antinociceptive effects of opioid μ agonists are modulated by δ agonists, the development of antinociceptive tolerance is not.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalEuropean Journal of Pharmacology
Volume186
Issue number1
DOIs
StatePublished - Sep 4 1990

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Morphine
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Keywords

  • Antinociception
  • Morphine
  • Tolerance
  • δ-Opioid receptor agonists

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Selective modulation of morphine antinociception, but not development of tolerance, by δ receptor agonists. / Qi, Jiang; Mosberg, Henry I.; Porreca, Frank.

In: European Journal of Pharmacology, Vol. 186, No. 1, 04.09.1990, p. 137-141.

Research output: Contribution to journalArticle

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