Selenium and colorectal adenoma

Results of a pooled analysis

Elizabeth T Jacobs, Ruiyun Jiang, David S Alberts, E. Robert Greenberg, Elaine W. Gunter, Margaret R. Karagas, Elaine Lanza, Luke Ratnasinghe, Mary E. Reid, Arthur Schatzkin, Stephanie A. Smith-Warner, Kristin Wallace, María Elena Martínez

Research output: Contribution to journalArticle

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Abstract

Background: Secondary analyses of data from a large randomized clinical trial have suggested that intake of the trace element selenium reduces risk of colorectal neoplasia, but epidemiologic studies have not shown a consistent protective association. Methods: We conducted a combined analysis of data from three randomized trials - the Wheat Bran Fiber Trial, the Polyp Prevention Trial, and the Polyp Prevention Study - which tested the effects of various nutritional interventions for colorectal adenoma prevention among participants who recently had an adenoma removed during colonoscopy. Selenium concentrations were measured from blood specimens from a total of 1763 trial participants, and quartiles of baseline selenium were established from the pooled data. To estimate the association between baseline selenium and colorectal adenoma risk, odds ratios (ORs) and 95% confidence intervals (Cls) were calculated using logistic regression modeling. All statistical tests were two-sided. Results: Individual study results among participants whose blood selenium concentrations were in the highest versus the lowest quartile varied in magnitude (Polyp Prevention Trial: OR = 0.67, 95% CI = 0.43 to 1.05; Ptrend = .21; Wheat Bran Fiber Trial: OR = 0.66, 95% CI = 0.40 to 1.10; Ptrend = .13, and Polyp Prevention Study: OR = 0.57, 95% CI = 0.34 to 0.95, Ptrend = .04). Analyses of the pooled data showed that individuals whose blood selenium values were in the highest quartile (median = 150 ng/mL) had statistically significantly lower odds of developing a new adenoma compared with those in the lowest quartile (OR = 0.66, 95% CI = 0.50 to 0.87; Ptrend = .006). Conclusions: The inverse association between higher blood selenium concentration and adenoma risk supports previous findings indicating that higher selenium status may be related to decreased risk of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)1669-1675
Number of pages7
JournalJournal of the National Cancer Institute
Volume96
Issue number22
DOIs
StatePublished - Nov 17 2004

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Selenium
Adenoma
Odds Ratio
Polyps
Dietary Fiber
Trace Elements
Colonoscopy
Epidemiologic Studies
Colorectal Neoplasms
Randomized Controlled Trials
Logistic Models
Confidence Intervals
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Jacobs, E. T., Jiang, R., Alberts, D. S., Greenberg, E. R., Gunter, E. W., Karagas, M. R., ... Martínez, M. E. (2004). Selenium and colorectal adenoma: Results of a pooled analysis. Journal of the National Cancer Institute, 96(22), 1669-1675. https://doi.org/10.1093/jnci/djh310

Selenium and colorectal adenoma : Results of a pooled analysis. / Jacobs, Elizabeth T; Jiang, Ruiyun; Alberts, David S; Greenberg, E. Robert; Gunter, Elaine W.; Karagas, Margaret R.; Lanza, Elaine; Ratnasinghe, Luke; Reid, Mary E.; Schatzkin, Arthur; Smith-Warner, Stephanie A.; Wallace, Kristin; Martínez, María Elena.

In: Journal of the National Cancer Institute, Vol. 96, No. 22, 17.11.2004, p. 1669-1675.

Research output: Contribution to journalArticle

Jacobs, ET, Jiang, R, Alberts, DS, Greenberg, ER, Gunter, EW, Karagas, MR, Lanza, E, Ratnasinghe, L, Reid, ME, Schatzkin, A, Smith-Warner, SA, Wallace, K & Martínez, ME 2004, 'Selenium and colorectal adenoma: Results of a pooled analysis', Journal of the National Cancer Institute, vol. 96, no. 22, pp. 1669-1675. https://doi.org/10.1093/jnci/djh310
Jacobs, Elizabeth T ; Jiang, Ruiyun ; Alberts, David S ; Greenberg, E. Robert ; Gunter, Elaine W. ; Karagas, Margaret R. ; Lanza, Elaine ; Ratnasinghe, Luke ; Reid, Mary E. ; Schatzkin, Arthur ; Smith-Warner, Stephanie A. ; Wallace, Kristin ; Martínez, María Elena. / Selenium and colorectal adenoma : Results of a pooled analysis. In: Journal of the National Cancer Institute. 2004 ; Vol. 96, No. 22. pp. 1669-1675.
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abstract = "Background: Secondary analyses of data from a large randomized clinical trial have suggested that intake of the trace element selenium reduces risk of colorectal neoplasia, but epidemiologic studies have not shown a consistent protective association. Methods: We conducted a combined analysis of data from three randomized trials - the Wheat Bran Fiber Trial, the Polyp Prevention Trial, and the Polyp Prevention Study - which tested the effects of various nutritional interventions for colorectal adenoma prevention among participants who recently had an adenoma removed during colonoscopy. Selenium concentrations were measured from blood specimens from a total of 1763 trial participants, and quartiles of baseline selenium were established from the pooled data. To estimate the association between baseline selenium and colorectal adenoma risk, odds ratios (ORs) and 95{\%} confidence intervals (Cls) were calculated using logistic regression modeling. All statistical tests were two-sided. Results: Individual study results among participants whose blood selenium concentrations were in the highest versus the lowest quartile varied in magnitude (Polyp Prevention Trial: OR = 0.67, 95{\%} CI = 0.43 to 1.05; Ptrend = .21; Wheat Bran Fiber Trial: OR = 0.66, 95{\%} CI = 0.40 to 1.10; Ptrend = .13, and Polyp Prevention Study: OR = 0.57, 95{\%} CI = 0.34 to 0.95, Ptrend = .04). Analyses of the pooled data showed that individuals whose blood selenium values were in the highest quartile (median = 150 ng/mL) had statistically significantly lower odds of developing a new adenoma compared with those in the lowest quartile (OR = 0.66, 95{\%} CI = 0.50 to 0.87; Ptrend = .006). Conclusions: The inverse association between higher blood selenium concentration and adenoma risk supports previous findings indicating that higher selenium status may be related to decreased risk of colorectal cancer.",
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T1 - Selenium and colorectal adenoma

T2 - Results of a pooled analysis

AU - Jacobs, Elizabeth T

AU - Jiang, Ruiyun

AU - Alberts, David S

AU - Greenberg, E. Robert

AU - Gunter, Elaine W.

AU - Karagas, Margaret R.

AU - Lanza, Elaine

AU - Ratnasinghe, Luke

AU - Reid, Mary E.

AU - Schatzkin, Arthur

AU - Smith-Warner, Stephanie A.

AU - Wallace, Kristin

AU - Martínez, María Elena

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N2 - Background: Secondary analyses of data from a large randomized clinical trial have suggested that intake of the trace element selenium reduces risk of colorectal neoplasia, but epidemiologic studies have not shown a consistent protective association. Methods: We conducted a combined analysis of data from three randomized trials - the Wheat Bran Fiber Trial, the Polyp Prevention Trial, and the Polyp Prevention Study - which tested the effects of various nutritional interventions for colorectal adenoma prevention among participants who recently had an adenoma removed during colonoscopy. Selenium concentrations were measured from blood specimens from a total of 1763 trial participants, and quartiles of baseline selenium were established from the pooled data. To estimate the association between baseline selenium and colorectal adenoma risk, odds ratios (ORs) and 95% confidence intervals (Cls) were calculated using logistic regression modeling. All statistical tests were two-sided. Results: Individual study results among participants whose blood selenium concentrations were in the highest versus the lowest quartile varied in magnitude (Polyp Prevention Trial: OR = 0.67, 95% CI = 0.43 to 1.05; Ptrend = .21; Wheat Bran Fiber Trial: OR = 0.66, 95% CI = 0.40 to 1.10; Ptrend = .13, and Polyp Prevention Study: OR = 0.57, 95% CI = 0.34 to 0.95, Ptrend = .04). Analyses of the pooled data showed that individuals whose blood selenium values were in the highest quartile (median = 150 ng/mL) had statistically significantly lower odds of developing a new adenoma compared with those in the lowest quartile (OR = 0.66, 95% CI = 0.50 to 0.87; Ptrend = .006). Conclusions: The inverse association between higher blood selenium concentration and adenoma risk supports previous findings indicating that higher selenium status may be related to decreased risk of colorectal cancer.

AB - Background: Secondary analyses of data from a large randomized clinical trial have suggested that intake of the trace element selenium reduces risk of colorectal neoplasia, but epidemiologic studies have not shown a consistent protective association. Methods: We conducted a combined analysis of data from three randomized trials - the Wheat Bran Fiber Trial, the Polyp Prevention Trial, and the Polyp Prevention Study - which tested the effects of various nutritional interventions for colorectal adenoma prevention among participants who recently had an adenoma removed during colonoscopy. Selenium concentrations were measured from blood specimens from a total of 1763 trial participants, and quartiles of baseline selenium were established from the pooled data. To estimate the association between baseline selenium and colorectal adenoma risk, odds ratios (ORs) and 95% confidence intervals (Cls) were calculated using logistic regression modeling. All statistical tests were two-sided. Results: Individual study results among participants whose blood selenium concentrations were in the highest versus the lowest quartile varied in magnitude (Polyp Prevention Trial: OR = 0.67, 95% CI = 0.43 to 1.05; Ptrend = .21; Wheat Bran Fiber Trial: OR = 0.66, 95% CI = 0.40 to 1.10; Ptrend = .13, and Polyp Prevention Study: OR = 0.57, 95% CI = 0.34 to 0.95, Ptrend = .04). Analyses of the pooled data showed that individuals whose blood selenium values were in the highest quartile (median = 150 ng/mL) had statistically significantly lower odds of developing a new adenoma compared with those in the lowest quartile (OR = 0.66, 95% CI = 0.50 to 0.87; Ptrend = .006). Conclusions: The inverse association between higher blood selenium concentration and adenoma risk supports previous findings indicating that higher selenium status may be related to decreased risk of colorectal cancer.

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