Self-assembly of gold nanoparticles on e-beam nano-patterns towards protein nanoarray

Tremaine Powell, Jeong Yeol Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

As our understanding of human diseases grows, so does our need to understand functions and pathways on a proteomic level. Protein arrays are a way of analyzing proteins and pathways within single molecule detection. A new concept of fabricating protein arrays based on self assembly of protein/gold nanoparticle conjugates onto nanometer patterns formed by e-beam lithography. Hydrophilic gold nanoparticles (AuNPs) are formed using the Brust-Schiffrin method without stabilizer, and are exposed to a model hydrophobic surface with hydrophilic patterns etched within. The AuNPs bind to the exposed hydrophilic surfaces, while the hydrophobic surfaces repel the gold. This method can be used to bind different proteins to specific size AuNPs, which in turn, when serially added to nanometer patterns, will self assemble onto their respective sized patterns.

Original languageEnglish (US)
Title of host publication2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings
EditorsM. Laudon, B. Romanowicz
Pages351-354
Number of pages4
StatePublished - Dec 1 2005
Event2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 - Anaheim, CA, United States
Duration: May 8 2005May 12 2005

Publication series

Name2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings

Other

Other2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005
CountryUnited States
CityAnaheim, CA
Period5/8/055/12/05

ASJC Scopus subject areas

  • Engineering(all)

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    Powell, T., & Yoon, J. Y. (2005). Self-assembly of gold nanoparticles on e-beam nano-patterns towards protein nanoarray. In M. Laudon, & B. Romanowicz (Eds.), 2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings (pp. 351-354). (2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings).