Senescent synapses and hippocampal circuit dynamics

Sara N. Burke, Carol A Barnes

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Excitatory synaptic transmission is altered during aging in hippocampal granule cells, and in CA3 and CA1 pyramidal cells. These functional changes contribute to age-associated impairments in experimentally-induced plasticity in each of these primary hippocampal subregions. In CA1, plasticity evoked by stimulation shares common mechanisms with the synaptic modification observed following natural behavior. Aging results in deficits in both artificially- and behaviorally-induced plasticity, and this could in part reflect age-related changes in Ca2+ homeostasis. Other observations, however, suggest that increased intracellular Ca2+ levels are beneficial under some circumstances. This review focuses on age-associated changes in synaptic function, how these alterations might contribute to cognitive decline, and the extent to which altered hippocampal circuit properties are detrimental or reflect compensatory processes.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalTrends in Neurosciences
Volume33
Issue number3
DOIs
StatePublished - Mar 2010

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Pyramidal Cells
Synaptic Transmission
Synapses
Homeostasis
Cognitive Dysfunction

ASJC Scopus subject areas

  • Neuroscience(all)

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Senescent synapses and hippocampal circuit dynamics. / Burke, Sara N.; Barnes, Carol A.

In: Trends in Neurosciences, Vol. 33, No. 3, 03.2010, p. 153-161.

Research output: Contribution to journalArticle

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