Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction

J. D. Potts, E. B. Vincent, Raymond B Runyan, D. L. Weeks

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The formation of the valves in the heart is a spatially and temporally controlled process. A tissue interaction between the endothelium and its adjacent myocardium initiates the transformation of the endothelium into the mesenchymal precursors of the heart valve. One or more of the molecules implicated as critical for valve formation are members of the transforming growth factor β family of molecules. Presented here is a spatial and temporal analysis of TGFβ2 and TGFβ3 in the chick heart during valve formation. We show that TGFβ3 mRNA is concentrated in AV canal tissue where valve formation will occur, consistent with previous observations that TGFβ3 production is critical during valve formation. Additionally, an RNA complementary to TGFβ3 encoding mRNA is present in the heart. The temporally controlled appearance of RNA complementary to TGFβ3 suggests that this molecule may play a role in the regulation of TGFβ3 production in the heart.

Original languageEnglish (US)
Pages (from-to)340-345
Number of pages6
JournalDevelopmental Dynamics
Volume193
Issue number4
StatePublished - 1992
Externally publishedYes

Fingerprint

Heart Valves
Complementary RNA
Messenger RNA
Endothelium
Spatio-Temporal Analysis
Transforming Growth Factors
Myocardium

Keywords

  • Complementary mRNA
  • Growth factor
  • Heart development

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

Cite this

Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction. / Potts, J. D.; Vincent, E. B.; Runyan, Raymond B; Weeks, D. L.

In: Developmental Dynamics, Vol. 193, No. 4, 1992, p. 340-345.

Research output: Contribution to journalArticle

Potts, JD, Vincent, EB, Runyan, RB & Weeks, DL 1992, 'Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction', Developmental Dynamics, vol. 193, no. 4, pp. 340-345.
Potts, J. D. ; Vincent, E. B. ; Runyan, Raymond B ; Weeks, D. L. / Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction. In: Developmental Dynamics. 1992 ; Vol. 193, No. 4. pp. 340-345.
@article{a35dc22078cf4f3b817bf682565a0a00,
title = "Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction",
abstract = "The formation of the valves in the heart is a spatially and temporally controlled process. A tissue interaction between the endothelium and its adjacent myocardium initiates the transformation of the endothelium into the mesenchymal precursors of the heart valve. One or more of the molecules implicated as critical for valve formation are members of the transforming growth factor β family of molecules. Presented here is a spatial and temporal analysis of TGFβ2 and TGFβ3 in the chick heart during valve formation. We show that TGFβ3 mRNA is concentrated in AV canal tissue where valve formation will occur, consistent with previous observations that TGFβ3 production is critical during valve formation. Additionally, an RNA complementary to TGFβ3 encoding mRNA is present in the heart. The temporally controlled appearance of RNA complementary to TGFβ3 suggests that this molecule may play a role in the regulation of TGFβ3 production in the heart.",
keywords = "Complementary mRNA, Growth factor, Heart development",
author = "Potts, {J. D.} and Vincent, {E. B.} and Runyan, {Raymond B} and Weeks, {D. L.}",
year = "1992",
language = "English (US)",
volume = "193",
pages = "340--345",
journal = "Developmental Dynamics",
issn = "1058-8388",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction

AU - Potts, J. D.

AU - Vincent, E. B.

AU - Runyan, Raymond B

AU - Weeks, D. L.

PY - 1992

Y1 - 1992

N2 - The formation of the valves in the heart is a spatially and temporally controlled process. A tissue interaction between the endothelium and its adjacent myocardium initiates the transformation of the endothelium into the mesenchymal precursors of the heart valve. One or more of the molecules implicated as critical for valve formation are members of the transforming growth factor β family of molecules. Presented here is a spatial and temporal analysis of TGFβ2 and TGFβ3 in the chick heart during valve formation. We show that TGFβ3 mRNA is concentrated in AV canal tissue where valve formation will occur, consistent with previous observations that TGFβ3 production is critical during valve formation. Additionally, an RNA complementary to TGFβ3 encoding mRNA is present in the heart. The temporally controlled appearance of RNA complementary to TGFβ3 suggests that this molecule may play a role in the regulation of TGFβ3 production in the heart.

AB - The formation of the valves in the heart is a spatially and temporally controlled process. A tissue interaction between the endothelium and its adjacent myocardium initiates the transformation of the endothelium into the mesenchymal precursors of the heart valve. One or more of the molecules implicated as critical for valve formation are members of the transforming growth factor β family of molecules. Presented here is a spatial and temporal analysis of TGFβ2 and TGFβ3 in the chick heart during valve formation. We show that TGFβ3 mRNA is concentrated in AV canal tissue where valve formation will occur, consistent with previous observations that TGFβ3 production is critical during valve formation. Additionally, an RNA complementary to TGFβ3 encoding mRNA is present in the heart. The temporally controlled appearance of RNA complementary to TGFβ3 suggests that this molecule may play a role in the regulation of TGFβ3 production in the heart.

KW - Complementary mRNA

KW - Growth factor

KW - Heart development

UR - http://www.scopus.com/inward/record.url?scp=0026659425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026659425&partnerID=8YFLogxK

M3 - Article

C2 - 1511174

AN - SCOPUS:0026659425

VL - 193

SP - 340

EP - 345

JO - Developmental Dynamics

JF - Developmental Dynamics

SN - 1058-8388

IS - 4

ER -