@article{603e31c603b741daa843fd0defbf2247,
title = "Sensitivity to change and association of three-dimensional meniscal measures with radiographic joint space width loss in rapid clinical progression of knee osteoarthritis",
abstract = "Objective: To determine whether 3D meniscal measures had similar sensitivity to longitudinal change as cartilage thickness; to what extent these measures are associated with longitudinal joint space width (JSW) change; and whether the latter associations differ between minimum (mJSW) and fixed-location JSW. Methods: Two-year changes in medial meniscal position and morphology, cartilage thickness (MRI) and minimum and fixed-location JSW (radiography) were determined in 35 Osteoarthritis Initiative knees [12 men, age: 67 (51-77) years; 23 women, age: 65 (54-78) years], progressing from baseline Kellgren-Lawrence grade ≤2 to knee replacement within 3-5 years. Multiple linear regression assessed the features contributing to JSW change. Results: Meniscal measures, cartilage thickness and JSW displayed similar sensitivity to change (standardised response mean≤|0.76|). Meniscal changes were strongly associated with JSW change (r≤|0.66|), adding ≤20% to its variance in addition to cartilage thickness change. Fixed-location JSW change (multiple r2=72%) was more strongly related to cartilage and meniscal change than mJSW (61%). Meniscal morphology explained more of fixed-location JSW and meniscal position more of mJSW. Conclusion: Meniscal measures provide independent information in explaining the variance of radiographic JSW change. Fixed-location JSW appears to be more reflective of structural change than mJSW and, hence, a potentially superior measure of structural progression. Key Points: • 3D positional/morphological meniscal measures change in rapidly progressing knees. • Similar sensitivity to 2-year change of quantitative meniscal/cartilage measures in rapid progression. • Changes in meniscal measures are strongly associated with radiographic JSW change. • Meniscal change provides information to explain JSW variance independent of cartilage. • Fixed-location JSW reflects structural disease stage more closely than minimum JSW.",
keywords = "Cartilage thickness, Joint space width, Knee osteoarthritis, Magnetic resonance imaging, Meniscus",
author = "Melanie Roth and Katja Emmanuel and Wolfgang Wirth and Kwoh, {C. Kent} and Hunter, {David J.} and Felix Eckstein",
note = "Funding Information: Conflict of interest The authors of this manuscript declare relationships with the following companies: Wolfgang Wirth has a part time employment with Chondrometrics GmbH and is a co-owner of Chondrometrics GmbH, a company providing MR image analysis services to academic researchers and to industry. C. Kent Kwoh has received research support from Merck Serono and Abbvie. David J. Hunter is supported by an NHMRC practitioner Fellowship and consults for Flexion, Merck Serono and TissueGene. Felix Eckstein is CEO and CMO of Chondrometrics GmbH; he has provided consulting services to Merck Serono, Bioclinica/Synarc, Samumed and Abbvie, has prepared educational sessions for Medtronic, and has received research support from Pfizer, Eli Lilly, Merck Serono, Novartis, Stryker, Abbvie, Kolon/ Tissue Gene, Synarc, Ampio, BICL and Orthotrophix. Katja Emmanuel and Melanie Roth declare no relationships with any companies, whose products or services may be related to the subject matter of the article. Funding Information: Open access funding provided by Paracelsus Medical University. The authors of this manuscript declare relationships with the following companies: Wolfgang Wirth has a part time employment with Chondrometrics GmbH and is a co-owner of Chondrometrics GmbH, a company providing MR image analysis services to academic researchers and to industry. C. Kent Kwoh has received research support from Merck Serono and Abbvie. David J. Hunter is supported by an NHMRC practitioner Fellowship and consults for Flexion, Merck Serono and TissueGene. Felix Eckstein is CEO and CMO of Chondrometrics GmbH; he has provided consulting services to Merck Serono, Bioclinica/Synarc, Samumed and Abbvie, has prepared educational sessions for Medtronic, and has received research support from Pfizer, Eli Lilly, Merck Serono, Novartis, Stryker, Abbvie, Kolon/Tissue Gene, Synarc, Ampio, BICL and Orthotrophix. Katja Emmanuel and Melanie Roth declare no relationships with any companies, whose products or services may be related to the subject matter of the article. Funding Information: Funding The study and image acquisition was supported by the Osteoarthritis Initiative (OAI), a public-private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health (_100000002), a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Pfizer, Inc. (_100004319); Novartis Pharmaceuticals Corporation; Merck Research Laboratories; and GlaxoSmithKline (_501100002066). Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health (_100000009). The image analysis of this study was partly funded by Novartis Pharma AG (Basel, Switzerland), by Merck KGaA (Darmstadt, Germany), by a contract with the University of Pittsburgh (Pivotal OAI MRI Analyses POMA: NIH/NHLBI Contract No. HHSN2682010000 21C), by a vendor contract from the OAI Coordinating Center at University of California, San Francisco (N01-AR-2-2258), and by an ancillary grant to the OAI held by Northwestern University (NIH/ NIAMS R01 AR052918 [Sharma]). The sponsors were not involved in the design and conduct of this particular study, in the analysis and interpretation of the data, and in the preparation, review, or approval of the manuscript. Publisher Copyright: {\textcopyright} 2017, The Author(s).",
year = "2018",
month = may,
day = "1",
doi = "10.1007/s00330-017-5140-1",
language = "English (US)",
volume = "28",
pages = "1844--1853",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "5",
}