Sequelae of lateral ovarian transposition in irradiated cervical cancer patients

Setsuko K Chambers, Joseph T. Chambers, Ruben Kier, Richard E. Peschel

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Lateral ovarian transposition (LOT) is a useful technique for preserving ovarian function in "high-risk" premenopausal Stage I cervix cancer patients who undergo hysterectomy and subsequent postoperative whole pelvic radiation therapy. From 1978 to 1988, 38 FIGO Stage I cervical cancer patients underwent LOT as part of their initial operative procedure and 14 of these patients (37%) subsequently received pelvic radiation therapy (LOT + RT) because of pathological findings such as metastatic pelvic lymph node involvement or positive surgical margins(13 patients) or recurrent disease (1 patient). Ten (71%) of the 14 (LOT + RT) patients have maintained ovarian function with a median follow-up of 35 months. Preservation of ovarian function was directly related to the estimated scatter dose to the ovaries. For patients whose estimated ovarian dose was 300 cGy or less, only 1 of 9 patients (11%) underwent menopause, whereas 3 of 5 patients (60%) became menopausal if the ovarian dose was more than 300 cGy. The placement of the ovaries was also crucial for preservation of ovarian function, with 100% of the patients developing menopause if the ovaries were placed below the iliac crest. A major side effect of LOT was the development of symptomatic ovarian cysts in 7 (18%) of the 38 Stage I patients who underwent LOT. In the 24 patients who underwent LOT alone without RT, the incidence of symptomatic ovarian cysts was 25% compared to only 7% of the patients who underwent LOT + RT, although this difference was not statistically significant (p = .18).

Original languageEnglish (US)
Pages (from-to)1305-1308
Number of pages4
JournalInternational Journal of Radiation Oncology Biology Physics
Volume20
Issue number6
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Uterine Cervical Neoplasms
cancer
ovaries
Ovary
Ovarian Cysts
cysts
Menopause
dosage
radiation therapy
Radiotherapy
lymphatic system
Operative Surgical Procedures
Hysterectomy
preserving
margins
incidence
Lymph Nodes

Keywords

  • Cervix cancer
  • Ovarian transposition
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Sequelae of lateral ovarian transposition in irradiated cervical cancer patients. / Chambers, Setsuko K; Chambers, Joseph T.; Kier, Ruben; Peschel, Richard E.

In: International Journal of Radiation Oncology Biology Physics, Vol. 20, No. 6, 1991, p. 1305-1308.

Research output: Contribution to journalArticle

Chambers, Setsuko K ; Chambers, Joseph T. ; Kier, Ruben ; Peschel, Richard E. / Sequelae of lateral ovarian transposition in irradiated cervical cancer patients. In: International Journal of Radiation Oncology Biology Physics. 1991 ; Vol. 20, No. 6. pp. 1305-1308.
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