Sequence, stability, and structure of G-Quadruplexes and their interactions with drugs

Yuwei Chen, Danzhou Yang

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Although DNA is most widely known for its ability to store and pass along genetic information, the discovery of G-quadruplex structures has illuminated a new role for DNA in biology. DNA G-quadruplexes are four-stranded globular nucleic acid secondary structures formed in specific G-rich sequences with biological significance, such as human telomeres and oncogene promoters. This reviewfocuses on the unimolecularDNAG-quadruplexes, which can readily form in solution under physiological conditions and are considered to be the most biologically relevant. Available structural data show a great conformational diversity of unimolecular G-quadruplexes, which are amenable to small-molecule drug targeting. The relationships between sequence, structure, and stability of unimolecular DNA G-quadruplexes, as well as the recent progress on interactions with small-molecule compounds and insights into rational design of G-quadruplex-interactive molecules, will be discussed. Curr. Protoc. Nucleic Acid Chem. 50:17.5.1-17.5.17.

Original languageEnglish (US)
Article number17.5
JournalCurrent Protocols in Nucleic Acid Chemistry
Issue numberSUPLL.50
DOIs
StatePublished - Sep 1 2012

Keywords

  • G-quadruplexes
  • Human telomeres
  • Oncogene promoters
  • Rational drug design
  • Small-molecule interactions

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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