Sequential catecholamine and serotonin depletion in mirtazapine-treated depressed patients

Pedro L. Delgado, Francisco Moreno, Larry Onate, Alan J. Gelenberg

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

This study was aimed at determining whether patient- or antidepressant-related variables are most important to the mood response to serotonin (5-HT) or catecholamine depletion. Depressed patients treated with open-label mirtazapine (≥ 6 wk) received two depletion tests (5-HT and catecholamine depletion) 1 wk apart. Both 5-HT and catecholamine depletion led to a partial return of depression in most patients. Antidepressant response to mirtazapine is dependent on its dual actions on norepinephrine and 5-HT neurotransmission. Mood response to tryptophan or catecholamine depletion is dependent on the pharmacological properties of the antidepressant being taken during depletion.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalInternational Journal of Neuropsychopharmacology
Volume5
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Catecholamines
Serotonin
Antidepressive Agents
Synaptic Transmission
Tryptophan
Norepinephrine
mirtazapine
Pharmacology
Depression

Keywords

  • Antidepressant
  • Major depression
  • Neurotransmitter depletion
  • Norepinephrine
  • Selective serotonin reuptake inhibitors
  • Sexual dysfunction

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Sequential catecholamine and serotonin depletion in mirtazapine-treated depressed patients. / Delgado, Pedro L.; Moreno, Francisco; Onate, Larry; Gelenberg, Alan J.

In: International Journal of Neuropsychopharmacology, Vol. 5, No. 1, 2002, p. 63-66.

Research output: Contribution to journalArticle

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