Serologic screening for genital herpes infection: US preventive services task force recommendation statement

Kirsten Bibbins-Domingo, David C. Grossman, Susan J. Curry, Karina W. Davidson, John W. Epling, Francisco A.R. García, Alex R. Kemper, Alex H. Krist, Ann E. Kurth, C. Seth Landefeld, Carol M. Mangione, William R. Phillips, Maureen G. Phipps, Michael P. Pignone, Michael Silverstein, Chien Wen Tseng

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

IMPORTANCE Genital herpes is a prevalent sexually transmitted infection in the United States, occurring in almost 1 in 6 persons aged 14 to 49 years. Infection is caused by 2 subtypes of the herpes simplex virus (HSV), HSV-1 and HSV-2. Antiviral medications may provide symptomatic relief from outbreaks but do not cure HSV infection. Neonatal herpes infection, while uncommon, can result in substantial morbidity and mortality. OBJECTIVE To update the 2005 US Preventive Services Task Force (USPSTF) recommendation on screening for genital herpes. EVIDENCE REVIEW The USPSTF reviewed the evidence on the accuracy, benefits, and harms of serologic screening for HSV-2 infection in asymptomatic persons, including those who are pregnant, as well as the effectiveness and harms of preventive medications and behavioral counseling interventions to reduce future symptomatic episodes and transmission to others. FINDINGS Based on the natural history of HSV infection, its epidemiology, and the available evidence on the accuracy of serologic screening tests, the USPSTF concluded that the harms outweigh the benefits of serologic screening for genital HSV infection in asymptomatic adolescents and adults, including those who are pregnant. CONCLUSIONS AND RECOMMENDATION The USPSTF recommends against routine serologic screening for genital HSV infection in asymptomatic adolescents and adults, including those who are pregnant. (D recommendation).

Original languageEnglish (US)
Pages (from-to)2525-2530
Number of pages6
JournalJAMA - Journal of the American Medical Association
Volume316
Issue number23
DOIs
StatePublished - Dec 20 2016

ASJC Scopus subject areas

  • Medicine(all)

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    Bibbins-Domingo, K., Grossman, D. C., Curry, S. J., Davidson, K. W., Epling, J. W., García, F. A. R., Kemper, A. R., Krist, A. H., Kurth, A. E., Landefeld, C. S., Mangione, C. M., Phillips, W. R., Phipps, M. G., Pignone, M. P., Silverstein, M., & Tseng, C. W. (2016). Serologic screening for genital herpes infection: US preventive services task force recommendation statement. JAMA - Journal of the American Medical Association, 316(23), 2525-2530. https://doi.org/10.1001/jama.2016.16776