Serologic studies in hairy cell leukemia: High prevalence of Epstein-Barr and cytomegalovirus antibodies and absence of human T-cell lymphotrophic viruses antibodies

Jorge R. Quesada, James Reuben, Roy L. Hopfer, Francis K. Mundon, Evan M. Hersh

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Serum from 60 patients with hairy cell leukemia (HCL) were studied for the presence and the titers of antibodies to Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human T-cell lymphotrophic viruses (HTLV). Eighty-three percent of the patients were seropositive for EBV, with a (reciprocal) geometric mean titer (GMT) of 960. Seventy-eight percent of the patients had antibodies to CMV with a GMT of 435. All 21 patients tested for HTLV I and HTLV III were seronegative; only one patient showed detectable antibodies to HTLV II. The potential role of these infections in the physiopathology of HCL is discussed.

Original languageEnglish (US)
Pages (from-to)1169-1173
Number of pages5
JournalLeukemia Research
Volume10
Issue number10
DOIs
StatePublished - 1986

Keywords

  • Epstein-Barr virus
  • Hairy cell leukemia
  • cytomegalovirus
  • human T-cell leukemia viruses
  • serologic studies
  • viral antibodies

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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