Serum amyloid P component and systemic fungal infection: Does it protect the host or is it a Trojan horse?

Stephen A Klotz, Richard E Sobonya, Peter N. Lipke, Melissa C. Garcia-Sherman

Research output: Contribution to journalArticle

7 Scopus citations


It is a striking observation that tissue of patients invaded by the deep mycoses often lacks evidence of an inflammatory response. This lack of host response is often attributed to neutropenia secondary to chemotherapy. However, systematic studies do not support this simplistic explanation. However, invasive fungal lesions are characterized by abundant fungal functional amyloid, which in turn is bound by serum amyloid P component (SAP). We postulate that SAP is important in the local immune response in invasive fungal infections. The interaction between fungal functional amyloid, SAP, and the immune response in deep mycoses is discussed.

Original languageEnglish (US)
Article numberofw166
JournalOpen Forum Infectious Diseases
Issue number3
StatePublished - 2016



  • Amyloid
  • Candidiasis
  • Functional amyloid
  • Fungi
  • Serum amyloid P component

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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