Serum uric acid and risk of ischemic stroke

The ARIC Study

Atsushi Hozawa, Aaron R. Folsom, Hassan Ibrahim, F. Javier Nieto, Wayne D. Rosamond, Eyal Shahar

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Aims: Since serum uric acid (UA) is strongly associated with cardiovascular risk factors, it has been debated whether serum UA is a stroke risk factor or whether UA may be simply "marking" subjects with other, causal risk factors. We therefore investigated the relation between UA and ischemic stroke in the Atherosclerosis Risk in Communities (ARIC) Study. Methods and results: Of 15,792 ARIC participants, 13,413 who were free of recognized stroke or coronary heart disease (CHD) at baseline and had a baseline UA measurement were included in the analysis. We followed the participants for ischemic stroke incidence (N = 381) over 12.6 years. Although serum UA was independently and positively related to ischemic stroke incidence when we adjusted for age, sex, race, and education, the positive relation was weakened when additionally adjusted for possible confounding variables. The positive multivariate-adjusted association between serum UA and ischemic stroke was observed among subjects not using diuretics (adjusted relative hazard in the highest quartile versus the lowest: relative hazard (RH) = 1.49; 95% confidence interval (CI): 1.00-2.23) (P for trend: 0.02), but not among diuretic users (P for interaction: 0.08). Conclusion: Our findings suggest that UA is an independent predictor of ischemic stroke among subjects not using diuretics, but that elevated UA itself may not cause ischemic stroke.

Original languageEnglish (US)
Pages (from-to)401-407
Number of pages7
JournalAtherosclerosis
Volume187
Issue number2
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Uric Acid
Atherosclerosis
Stroke
Serum
Diuretics
Confounding Factors (Epidemiology)
Sex Education
Incidence
Coronary Disease
Confidence Intervals

Keywords

  • Diuretics
  • Prospective studies
  • Stroke
  • Uric acid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hozawa, A., Folsom, A. R., Ibrahim, H., Javier Nieto, F., Rosamond, W. D., & Shahar, E. (2006). Serum uric acid and risk of ischemic stroke: The ARIC Study. Atherosclerosis, 187(2), 401-407. https://doi.org/10.1016/j.atherosclerosis.2005.09.020

Serum uric acid and risk of ischemic stroke : The ARIC Study. / Hozawa, Atsushi; Folsom, Aaron R.; Ibrahim, Hassan; Javier Nieto, F.; Rosamond, Wayne D.; Shahar, Eyal.

In: Atherosclerosis, Vol. 187, No. 2, 08.2006, p. 401-407.

Research output: Contribution to journalArticle

Hozawa, A, Folsom, AR, Ibrahim, H, Javier Nieto, F, Rosamond, WD & Shahar, E 2006, 'Serum uric acid and risk of ischemic stroke: The ARIC Study', Atherosclerosis, vol. 187, no. 2, pp. 401-407. https://doi.org/10.1016/j.atherosclerosis.2005.09.020
Hozawa, Atsushi ; Folsom, Aaron R. ; Ibrahim, Hassan ; Javier Nieto, F. ; Rosamond, Wayne D. ; Shahar, Eyal. / Serum uric acid and risk of ischemic stroke : The ARIC Study. In: Atherosclerosis. 2006 ; Vol. 187, No. 2. pp. 401-407.
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