Sesquiterpene quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran desert

E. M.Kithsiri Wijeratne, Priyani A. Paranagama, Marilyn T. Marron, Malkanthi K. Gunatilaka, A. Elizabeth Arnold, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Five new metabolites, (+)-(5S,10S)-4′-hydroxymethylcyclozonarone (1), 3-ketotauranin (3), 3α-hydroxytauranin (4), 12-hydroxytauranin (5), and phyllospinarone (6), together with tauranin (2), were isolated from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis. The structures of the new compounds were determined on the basis of their 1D and 2D NMR spectroscopic data and chemical interconversions. All compounds were evaluated for inhibition of cell proliferation in a panel of five cancer cell lines, and only tauranin (2) showed activity. When tested in a flow cytometry-based assay, tauranin induced apoptosis in PC-3M and NIH 3T3 cell lines.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalJournal Of Natural Products
Volume71
Issue number2
DOIs
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Sesquiterpene quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran desert'. Together they form a unique fingerprint.

Cite this