Sesquiterpenes and other constituents of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp.

Han Wei, Ya Ming Xu, Patricia Espinosa-Artiles, Manping X. Liu, Jiang Guang Luo, Jana M. U'Ren, A. Elizabeth Arnold, A. A. Leslie Gunatilaka

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Oxygenated guaiane-type sesquiterpenes, xylaguaianols A-D (1-4), an iso-cadinane-type sesquiterpene isocadinanol A (5), and an α-pyrone 9-hydroxyxylarone (6), together with five known sesquiterpenes (7-11), and four known cytochalasins (12-15) were isolated from a culture broth of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp. The structures of all compounds were elucidated by the analysis of their spectroscopic data and relative configurations of 1-5 were determined with the help of NMR NOESY experiments. Cytochalasins C (12), D (13), and Q (14) were investigated for their cytotoxic activity against five tumor cell lines. Cytochalasin D showed significant cytotoxicity against all five cell lines, with IC50s ranging from 0.22 to 1.44 μM, whereas cytochalasins C and Q exhibited moderate, but selective cytotoxicity.

Original languageEnglish (US)
Pages (from-to)102-108
Number of pages7
JournalPhytochemistry
Volume118
DOIs
StatePublished - Mar 27 2015

Fingerprint

Hypnum
Xylaria
cytochalasins
Endophytes
Bryophyta
Sesquiterpenes
Cytotoxicity
endophytes
sesquiterpenoids
mosses and liverworts
Guaiane Sesquiterpenes
Cells
Cytochalasins
Pyrones
Cytochalasin D
cytotoxicity
Tumor Cell Line
cell lines
pyrones
cytochalasin D

Keywords

  • Cytochalasins
  • Fungal endophyte
  • Hypnum sp.
  • Sesquiterpenes
  • Xylaguaianols
  • Xylaria sp.
  • α-Pyrone

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Horticulture

Cite this

Sesquiterpenes and other constituents of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp. / Wei, Han; Xu, Ya Ming; Espinosa-Artiles, Patricia; Liu, Manping X.; Luo, Jiang Guang; U'Ren, Jana M.; Elizabeth Arnold, A.; Leslie Gunatilaka, A. A.

In: Phytochemistry, Vol. 118, 27.03.2015, p. 102-108.

Research output: Contribution to journalArticle

Wei, Han ; Xu, Ya Ming ; Espinosa-Artiles, Patricia ; Liu, Manping X. ; Luo, Jiang Guang ; U'Ren, Jana M. ; Elizabeth Arnold, A. ; Leslie Gunatilaka, A. A. / Sesquiterpenes and other constituents of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp. In: Phytochemistry. 2015 ; Vol. 118. pp. 102-108.
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