Setting the tone

Superficial dorsal horn projection neurons regulate pain sensitivity

Patrick W Mantyh, Stephen P. Hunt

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The neurokinin-1 receptor is expressed by lamina I projection neurons of the spinal cord that are crucial for regulating pain behavior. These neurons are nocispecific, support long-term potentiation and appear to downregulate the K +-Cl - exporter channel KCC2 following peripheral nerve damage, leading to increased excitability. These lamina I neurons project to the brainstem and thalamus and modulate descending inhibitory and excitatory pathways to the dorsal horn that regulate nociceptive traffic.

Original languageEnglish (US)
Pages (from-to)582-584
Number of pages3
JournalTrends in Neurosciences
Volume27
Issue number10
DOIs
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

Posterior Horn Cells
Neurons
Pain
Neurokinin-1 Receptors
Long-Term Potentiation
Thalamus
Peripheral Nerves
Brain Stem
Spinal Cord
Down-Regulation
Spinal Cord Dorsal Horn

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Setting the tone : Superficial dorsal horn projection neurons regulate pain sensitivity. / Mantyh, Patrick W; Hunt, Stephen P.

In: Trends in Neurosciences, Vol. 27, No. 10, 10.2004, p. 582-584.

Research output: Contribution to journalArticle

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