Setting the tone: Superficial dorsal horn projection neurons regulate pain sensitivity

Patrick W. Mantyh, Stephen P. Hunt

Research output: Contribution to journalShort survey

55 Scopus citations

Abstract

The neurokinin-1 receptor is expressed by lamina I projection neurons of the spinal cord that are crucial for regulating pain behavior. These neurons are nocispecific, support long-term potentiation and appear to downregulate the K +-Cl - exporter channel KCC2 following peripheral nerve damage, leading to increased excitability. These lamina I neurons project to the brainstem and thalamus and modulate descending inhibitory and excitatory pathways to the dorsal horn that regulate nociceptive traffic.

Original languageEnglish (US)
Pages (from-to)582-584
Number of pages3
JournalTrends in Neurosciences
Volume27
Issue number10
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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