Seventy-two hour gas exchange performance and hemodynamic properties of NOVALUNG®iLA as a gas exchanger for arteriovenous carbon dioxide removal

Xiaoqin Zhou, David B. Loran, Dongfang Wang, Brannon R. Hyde, Scott D Lick, Joseph B. Zwischenberger

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: Acute respiratory failure is complicated by acidosis and altered end-organ perfusion. NOVA-LUNG®iLA is an interventional lung assist (ILA) device for arteriovenous carbon dioxide removal (AVCO2R). The present study was conducted to evaluate the device for short-term CO2 removal performance and hemodynamic response. Methods: Six adult sheep received cannulation of the jugular vein and carotid artery. The ILA-AVCO2R circuit was placed on the sheep for 72 hours. Hemodynamics and PaCO2 were measured; CO2 removal was calculated while varying sweep gas flow rates (Qg), device blood flow rates (Qb), and PaCO2. Results: Hemodynamic variables remained normal throughout the 72 hour study. CO2 removal increased with increases in Qg or Qb. Mean CO2 removal was 119.3 ml/min for Qb 1 L/min, Qg 5 L/min, and PaCO2 40-50 mmHg. PaCO2 was directly proportional to CO2 clearance (R=0.72, p <0.001). Conclusion: NOVALUNG®iLA can provide near total CO2 removal with Qb 1-2 L/min, Qg 5 L/min, and minimal flow resistance (3.88±0.82 mmHg/L/min). PaCO2, correlates with CO2 removal and is dependent on Qb and Qg.

Original languageEnglish (US)
Pages (from-to)303-308
Number of pages6
JournalPerfusion
Volume20
Issue number6
DOIs
StatePublished - 2005
Externally publishedYes

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Hemodynamics
Carbon Dioxide
Carbon dioxide
Gases
Equipment and Supplies
Sheep
performance
Lung
Jugular Veins
Acidosis
Carotid Arteries
Catheterization
Respiratory Insufficiency
Perfusion
Flow rate
Flow of gases
Blood
Networks (circuits)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Seventy-two hour gas exchange performance and hemodynamic properties of NOVALUNG®iLA as a gas exchanger for arteriovenous carbon dioxide removal. / Zhou, Xiaoqin; Loran, David B.; Wang, Dongfang; Hyde, Brannon R.; Lick, Scott D; Zwischenberger, Joseph B.

In: Perfusion, Vol. 20, No. 6, 2005, p. 303-308.

Research output: Contribution to journalArticle

Zhou, Xiaoqin ; Loran, David B. ; Wang, Dongfang ; Hyde, Brannon R. ; Lick, Scott D ; Zwischenberger, Joseph B. / Seventy-two hour gas exchange performance and hemodynamic properties of NOVALUNG®iLA as a gas exchanger for arteriovenous carbon dioxide removal. In: Perfusion. 2005 ; Vol. 20, No. 6. pp. 303-308.
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