Sex differences in amygdala activation during the perception of facial affect

William Killgore, D. A. Yurgelun-Todd

Research output: Contribution to journalArticle

195 Citations (Scopus)

Abstract

The cognitive and affective systems of the cerebral cortex are often more lateralized in males than females, but it is unclear whether these differences extend to subcortical systems. We used fMRI to examine sex differences in lateralized amygdala activity during happy and fearful face perception. Amygdala activation differed for men and women depending on the valence of the expression. Overall, males were more lateralized than females, but the direction differed between valence conditions. Happy faces produced greater right than left amygdala activation for males but not females. Both sexes showed greater left amygdala activation for fearful faces. These findings suggest that the lateralization of affective function may extend beyond the cortex to subcortical regions such as the amygdala.

Original languageEnglish (US)
Pages (from-to)2543-2547
Number of pages5
JournalNeuroReport
Volume12
Issue number11
StatePublished - Aug 8 2001
Externally publishedYes

Fingerprint

Amygdala
Sex Characteristics
Cerebral Cortex
Magnetic Resonance Imaging

Keywords

  • Affect
  • Amygdala
  • Cerebral laterality
  • Emotion
  • Faces
  • Fear
  • fMRI
  • Functional neuroimaging
  • Happy
  • Sex differences
  • Visual perception

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sex differences in amygdala activation during the perception of facial affect. / Killgore, William; Yurgelun-Todd, D. A.

In: NeuroReport, Vol. 12, No. 11, 08.08.2001, p. 2543-2547.

Research output: Contribution to journalArticle

Killgore, William ; Yurgelun-Todd, D. A. / Sex differences in amygdala activation during the perception of facial affect. In: NeuroReport. 2001 ; Vol. 12, No. 11. pp. 2543-2547.
@article{c61d6ec84ec1417f8c542c0fd66fff44,
title = "Sex differences in amygdala activation during the perception of facial affect",
abstract = "The cognitive and affective systems of the cerebral cortex are often more lateralized in males than females, but it is unclear whether these differences extend to subcortical systems. We used fMRI to examine sex differences in lateralized amygdala activity during happy and fearful face perception. Amygdala activation differed for men and women depending on the valence of the expression. Overall, males were more lateralized than females, but the direction differed between valence conditions. Happy faces produced greater right than left amygdala activation for males but not females. Both sexes showed greater left amygdala activation for fearful faces. These findings suggest that the lateralization of affective function may extend beyond the cortex to subcortical regions such as the amygdala.",
keywords = "Affect, Amygdala, Cerebral laterality, Emotion, Faces, Fear, fMRI, Functional neuroimaging, Happy, Sex differences, Visual perception",
author = "William Killgore and Yurgelun-Todd, {D. A.}",
year = "2001",
month = "8",
day = "8",
language = "English (US)",
volume = "12",
pages = "2543--2547",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Sex differences in amygdala activation during the perception of facial affect

AU - Killgore, William

AU - Yurgelun-Todd, D. A.

PY - 2001/8/8

Y1 - 2001/8/8

N2 - The cognitive and affective systems of the cerebral cortex are often more lateralized in males than females, but it is unclear whether these differences extend to subcortical systems. We used fMRI to examine sex differences in lateralized amygdala activity during happy and fearful face perception. Amygdala activation differed for men and women depending on the valence of the expression. Overall, males were more lateralized than females, but the direction differed between valence conditions. Happy faces produced greater right than left amygdala activation for males but not females. Both sexes showed greater left amygdala activation for fearful faces. These findings suggest that the lateralization of affective function may extend beyond the cortex to subcortical regions such as the amygdala.

AB - The cognitive and affective systems of the cerebral cortex are often more lateralized in males than females, but it is unclear whether these differences extend to subcortical systems. We used fMRI to examine sex differences in lateralized amygdala activity during happy and fearful face perception. Amygdala activation differed for men and women depending on the valence of the expression. Overall, males were more lateralized than females, but the direction differed between valence conditions. Happy faces produced greater right than left amygdala activation for males but not females. Both sexes showed greater left amygdala activation for fearful faces. These findings suggest that the lateralization of affective function may extend beyond the cortex to subcortical regions such as the amygdala.

KW - Affect

KW - Amygdala

KW - Cerebral laterality

KW - Emotion

KW - Faces

KW - Fear

KW - fMRI

KW - Functional neuroimaging

KW - Happy

KW - Sex differences

KW - Visual perception

UR - http://www.scopus.com/inward/record.url?scp=0035828156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035828156&partnerID=8YFLogxK

M3 - Article

C2 - 11496145

AN - SCOPUS:0035828156

VL - 12

SP - 2543

EP - 2547

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 11

ER -