Sex differences in angiotensin II-induced hypertension

B. Xue, A. K. Johnson, Meredith Hay

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Sex differences in the development of hypertension and cardiovascular disease have been described in humans and in animal models. In this paper we will review some of our studies which have as their emphasis the examination of the role of sex differences and sex steroids in modulating the central actions of angiotensin II (ANG II) via interactions with free radicals and nitric oxide, generating pathways within brain circumventricular organs and in central sympathomodulatory systems. Our studies indicate that low-dose infusions of ANG II result in hypertension in wild-type male mice but not in intact wild-type females. Furthermore, we have demonstrated that ANG II-induced hypertension in males is blocked by central infusions of the androgen receptor antagonist, flutamide, and by central infusions of the superoxide dismutase mimetic, tempol. We have also found that, in comparison to females, males show greater levels of intracellular reactive oxygen species in circumventricular organ neurons following long-term ANG II infusions. In female mice, ovariectomy, central blockade of estrogen receptors or total knockout of estrogen α receptors augments the pressor effects of ANG II. Finally, in females but not in males, central blockade of nitric oxide synthase increases the pressor effects of ANG II. Taken together, these results suggest that sex differences and estrogen and testosterone play important roles in the development of ANG II-induced hypertension.

Original languageEnglish (US)
Pages (from-to)727-734
Number of pages8
JournalBrazilian Journal of Medical and Biological Research
Volume40
Issue number5
StatePublished - May 2007
Externally publishedYes

Fingerprint

angiotensin II
gender differences
Sex Characteristics
Angiotensin II
hypertension
Hypertension
Estrogen Receptors
Androgen Receptor Antagonists
Flutamide
ovariectomy
mice
Ovariectomy
nitric oxide synthase
Nitric Oxide Synthase
cardiovascular diseases
testosterone
Neurons
Superoxide Dismutase
estrogens
Free Radicals

Keywords

  • Angiotensin II
  • Estrogen
  • Estrogen α and β receptors
  • Nitric oxide
  • Reactive oxygen species
  • Testosterone

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Medicine (miscellaneous)

Cite this

Sex differences in angiotensin II-induced hypertension. / Xue, B.; Johnson, A. K.; Hay, Meredith.

In: Brazilian Journal of Medical and Biological Research, Vol. 40, No. 5, 05.2007, p. 727-734.

Research output: Contribution to journalArticle

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